Cell Biology Antibodies 12
Anti-MYO5B Antibody (CAB8558)
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- SKU:
- CAB8558
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MYO5B Antibody |
| Antibody SKU: | CAB8558 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1440-1690 of human MYO5B (NP_001073936.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SKOV3, SW480 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1440-1690 of human MYO5B (NP_001073936.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AQAL AQSE RKRH ELNR QVTV QRKE KDFQ GMLE YHKE DEAL LIRN LVTD LKPQ MLSG TVPC LPAY ILYM CIRH ADYT NDDL KVHS LLTS TING IKKV LKKH NDDF EMTS FWLS NTCR LLHC LKQY SGDE GFMT QNTA KQNE HCLK NFDL TEYR QVLS DLSI QIYQ QLIK IAEG VLQP MIVS AMLE NESI QGLS GVKP TGYR KRSS SMAD GDNS YCLE AIIR QMNA FHTV MCDQ GLDP EIIL QVFK QLFY MIN |
| Gene ID: | 4645 |
| Uniprot: | Q9ULV0 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 47kDa/111kDa/213kDa |
| Observed MW: | 213kDa |
| Synonyms: | MYO5B, myosin VB |
| Background: | The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. |
| UniProt Protein Function: | MYO5B: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Defects in MYO5B are a cause of diarrhea type 2 (DIAR2). DIAR2 is characterized by onset of intractable life- threatening watery diarrhea during infancy. Two forms are recognized: early-onset MVID with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life. |
| UniProt Protein Details: | Protein type:Motor; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 18q21 Cellular Component: apical cortex; cytoplasmic vesicle membrane; protein complex; recycling endosome Molecular Function:microfilament motor activity; protein binding; Rab GTPase binding Biological Process: endosome localization; renal water homeostasis; vesicle-mediated transport Disease: Diarrhea 2, With Microvillus Atrophy |
| NCBI Summary: | The protein encoded by this gene, together with other proteins, may be involved in plasma membrane recycling. Mutations in this gene are associated with microvillous inclusion disease. [provided by RefSeq, Sep 2009] |
| UniProt Code: | Q9ULV0 |
| NCBI GenInfo Identifier: | 296439293 |
| NCBI Gene ID: | 4645 |
| NCBI Accession: | Q9ULV0.3 |
| UniProt Secondary Accession: | Q9ULV0,Q0P656, Q9H6Y6, B0I1R3, |
| UniProt Related Accession: | Q9ULV0 |
| Molecular Weight: | 47,983 Da |
| NCBI Full Name: | Unconventional myosin-Vb |
| NCBI Synonym Full Names: | myosin VB |
| NCBI Official Symbol: | MYO5B |
| NCBI Protein Information: | unconventional myosin-Vb |
| UniProt Protein Name: | Unconventional myosin-Vb |
| Protein Family: | Unconventional myosin |
| UniProt Gene Name: | MYO5B |
| UniProt Entry Name: | MYO5B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MYO5B antibody (CAB8558) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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