Cell Biology Antibodies 12

Anti-MYO5A Antibody (CAB9830)

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SKU:
CAB9830
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MYO5A Antibody
Antibody SKU:CAB9830
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human MYO5A (NP_000250.3).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Jurkat, MCF7, HT-1080, Mouse spleen, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 950-1150 of human MYO5A (NP_000250.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LTNL EGIY NSET EKLR SDLE RLQL SEEE AKVA TGRV LSLQ EEIA KLRK DLEQ TRSE KKCI EEHA DRYK QETE QLVS NLKE ENTL LKQE KEAL NHRI VQQA KEMT ETME KKLV EETK QLEL DLND ERLR YQNL LNEF SRLE ERYD DLKE EMTL MVHV PKPG HKRT DSTH SSNE SEYI FSSE IAEM EDIP SRTE EPSE KKVP L
Gene ID:4644
Uniprot:Q9Y4I1
Cellular Location:
Calculated MW:212kDa/215kDa/218kDa
Observed MW:240kDa
Synonyms:MYO5A, GS1, MYH12, MYO5, MYR12, myosin VA
Background:This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
UniProt Protein Function:Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation.
NCBI Summary:This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. [provided by RefSeq, Dec 2008]
UniProt Code:Q9Y4I1
NCBI GenInfo Identifier:215982791
NCBI Gene ID:4644
NCBI Accession:NP_000250.3
UniProt Secondary Accession:Q9Y4I1,O60653, Q07902, Q16249, Q9UE30, Q9UE31, A8MZC5
UniProt Related Accession:Q9Y4I1
Molecular Weight:
NCBI Full Name:unconventional myosin-Va isoform 1
NCBI Synonym Full Names:myosin VA
NCBI Official Symbol:MYO5A  
NCBI Official Synonym Symbols:GS1; MYO5; MYH12; MYR12  
NCBI Protein Information:unconventional myosin-Va
UniProt Protein Name:Unconventional myosin-Va
UniProt Synonym Protein Names:Dilute myosin heavy chain, non-muscle; Myosin heavy chain 12; Myosin-12; Myoxin
Protein Family:Unconventional myosin
UniProt Gene Name:MYO5A  
Anti-MYO5A Polyclonal Antibody (CAB9830)Western blot analysis of extracts of various cell lines, using MYO5A antibody (CAB9830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-MYO5A Polyclonal Antibody (CAB9830)Immunohistochemistry of paraffin-embedded rat kidney using MYO5A antibody (CAB9830) at dilution of 1:100 (40x lens).
Anti-MYO5A Polyclonal Antibody (CAB9830)Immunohistochemistry of paraffin-embedded human liver cancer using MYO5A antibody (CAB9830) at dilution of 1:100 (40x lens).
Anti-MYO5A Polyclonal Antibody (CAB9830)Immunohistochemistry of paraffin-embedded human prostate cancer using MYO5A antibody (CAB9830) at dilution of 1:100 (40x lens).
Anti-MYO5A Polyclonal Antibody (CAB9830)Immunohistochemistry of paraffin-embedded human rectum using MYO5A antibody (CAB9830) at dilution of 1:100 (40x lens).
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