Cell Biology Antibodies 12

Anti-MYO1A Antibody (CAB9272)

(No reviews yet) Write a Review
SKU:
CAB9272
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MYO1A Antibody
Antibody SKU:CAB9272
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 784-1043 of human MYO1A (NP_005370.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:Jurkat, HepG2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 784-1043 of human MYO1A (NP_005370.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VQKF LLGL KNNL PSTN VLDK TWPA APYK CLST ANQE LQQL FYQW KCKR FRDQ LSPK QVEI LREK LCAS ELFK GKKA SYPQ SVPI PFCG DYIG LQGN PKLQ KLKG GEEG PVLM AEAV KKVN RGNG KTSS RILL LTKG HVIL TDTK KSQA KIVI GLDN VAGV SVTS LKDG LFSL HLSE MSSV GSKG DFLL VSEH VIEL LTKM YRAV LDAT QRQL TVTV TEKF SVRF KENS VAVK VVQG PAGG DNSK LRYK KKGS HCLE VTVQ
Gene ID:4640
Uniprot:Q9UBC5
Cellular Location:
Calculated MW:118kDa
Observed MW:160kDa
Synonyms:MYO1A, BBMI, DFNA48, MIHC, MYHL, myosin IA
Background:This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene.
UniProt Protein Function:MYO1A: Involved in directing the movement of organelles along actin filaments (Potential). Defects in MYO1A are the cause of deafness autosomal dominant type 48 (DFNA48). DFNA48 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
UniProt Protein Details:

Protein type:Actin-binding; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: basolateral plasma membrane; brush border; cortical actin cytoskeleton; cytoplasm; filamentous actin; lateral plasma membrane; microvillus

Biological Process: sensory perception of sound; vesicle localization

Disease: Deafness, Autosomal Dominant 48

NCBI Summary:This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional skeletal muscle myosin-1 (MYH1). Unconventional myosins contain the basic domains characteristic of conventional myosins and are further distinguished from class members by their tail domains. They function as actin-based molecular motors. Mutations in this gene have been associated with autosomal dominant deafness. Alternatively spliced variants have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q9UBC5
NCBI GenInfo Identifier:13431715
NCBI Gene ID:4640
NCBI Accession:Q9UBC5.1
UniProt Secondary Accession:Q9UBC5,Q9UQD7,
UniProt Related Accession:Q9UBC5
Molecular Weight:118,401 Da
NCBI Full Name:Unconventional myosin-Ia
NCBI Synonym Full Names:myosin IA
NCBI Official Symbol:MYO1A  
NCBI Official Synonym Symbols:BBMI; MIHC; MYHL; DFNA48  
NCBI Protein Information:unconventional myosin-Ia
UniProt Protein Name:Unconventional myosin-Ia
UniProt Synonym Protein Names:Brush border myosin I; BBM-I; BBMI; Myosin I heavy chain; MIHC
Protein Family:Unconventional myosin
UniProt Gene Name:MYO1A  
UniProt Entry Name:MYO1A_HUMAN
Anti-MYO1A Polyclonal Antibody (CAB9272)Western blot analysis of extracts of various cell lines, using MYO1A antibody (CAB9272) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
View AllClose

0 Reviews

View AllClose

Related Products