Cell Biology Antibodies 12
Anti-MYO18A Antibody (CAB9015)
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- SKU:
- CAB9015
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MYO18A Antibody |
| Antibody SKU: | CAB9015 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1970-2054 of human MYO18A (NP_510880.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-251MG, HeLa, Jurkat, Mouse brain, Mouse liver, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1970-2054 of human MYO18A (NP_510880.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SDVD SELE DRVD GVKS WLSK NKGP SKAA SDDG SLKS SSPT SYWK SLAP DRSD DEHD PLDN TSRP RYSH SYLS DSDT EAKL TETN A |
| Gene ID: | 399687 |
| Uniprot: | Q92614 |
| Cellular Location: | Cytoplasm, Endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, cytoskeleton, trans-Golgi network |
| Calculated MW: | 180kDa/196kDa/226kDa/231kDa/233kDa |
| Observed MW: | 260kDa |
| Synonyms: | MYO18A, MAJN, MYSPDZ, SP-R210, SPR210 |
| Background: | The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. |
| UniProt Protein Function: | May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). |
| NCBI Summary: | The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016] |
| UniProt Code: | Q92614 |
| NCBI GenInfo Identifier: | 1093953577 |
| NCBI Gene ID: | 399687 |
| NCBI Accession: | NP_001333696.1 |
| UniProt Secondary Accession: | Q92614,Q5H9U3, Q5QD01, Q5W9F9, Q5W9G1, Q8IXP8, |
| UniProt Related Accession: | Q92614 |
| Molecular Weight: | 225 |
| NCBI Full Name: | unconventional myosin-XVIIIa isoform e |
| NCBI Synonym Full Names: | myosin XVIIIA |
| NCBI Official Symbol: | MYO18A |
| NCBI Official Synonym Symbols: | MAJN; MYSPDZ; SPR210; SP-R210 |
| NCBI Protein Information: | unconventional myosin-XVIIIa |
| UniProt Protein Name: | Unconventional myosin-XVIIIa |
| UniProt Synonym Protein Names: | Molecule associated with JAK3 N-terminus; MAJN; Myosin containing a PDZ domain; Surfactant protein receptor SP-R210 |
| UniProt Gene Name: | MYO18A |
 | Western blot analysis of extracts of various cell lines, using MYO18A antibody (CAB9015) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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