Cell Biology Antibodies 10

Anti-MYLK3 Antibody (CAB6663)

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SKU:
CAB6663
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MYLK3 Antibody
Antibody SKU:CAB6663
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MYLK3 (NP_872299.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MYLK3 (NP_872299.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSGT SKES LGHG GLPG LGKT CLTT MDTK LNML NEKV DQLL HFQE DVTE KLQS MCRD MGHL ERGL HRLE ASRA PGPG GADG VPHI DTQA GWPE VLEL VRAM QQDA AQHG ARLE ALFR MVAA VDRA IALV GATF QKSK VADF LMQG RVPW RRGS PGDS PEEN KERV EEEG GKPK HVLS TSGV QSDA REPG EESQ KADV LEGT AERL PPIR ASGL GADP AQAV VSPG QGDG VPGP AQAF PGHL
Gene ID:91807
Uniprot:Q32MK0
Cellular Location:Cytoplasm
Calculated MW:52kDa/88kDa
Observed MW:Refer to Figures
Synonyms:MYLK3, MLCK, MLCK2, caMLCK
Background:
UniProt Protein Function:caMLCK: Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:CAMK group; EC 2.7.11.18; Kinase, protein; MLCK family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 16q11.2

Cellular Component: actin cytoskeleton; cytoplasm; cytosol; intracellular

Molecular Function:ATP binding; calmodulin-dependent protein kinase activity; myosin light chain kinase activity

Biological Process: cardiac myofibril assembly; cellular response to interleukin-1; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid phosphorylation; regulation of vascular permeability during acute inflammatory response; sarcomere organization; sarcomerogenesis

NCBI Summary:Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
UniProt Code:Q32MK0
NCBI GenInfo Identifier:815930021
NCBI Gene ID:91807
NCBI Accession:NP_001295230.1
UniProt Secondary Accession:Q32MK0,Q96DV1,
UniProt Related Accession:Q32MK0
Molecular Weight:52,723 Da
NCBI Full Name:myosin light chain kinase 3 isoform 2
NCBI Synonym Full Names:myosin light chain kinase 3
NCBI Official Symbol:MYLK3  
NCBI Official Synonym Symbols:MLCK; MLCK2; caMLCK  
NCBI Protein Information:myosin light chain kinase 3
UniProt Protein Name:Myosin light chain kinase 3
UniProt Synonym Protein Names:Cardiac-MyBP-C-associated Ca/CaM kinase; Cardiac-MLCK
Protein Family:Myosin light chain kinase
UniProt Gene Name:MYLK3  
Anti-MYLK3 Antibody (CAB6663)Immunofluorescence analysis of U2OS cells using MYLK3 antibody (CAB6663). Blue: DAPI for nuclear staining.
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