Cell Biology Antibodies 12
Anti-MYL6 Antibody (CAB8557)
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- SKU:
- CAB8557
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MYL6 Antibody |
| Antibody SKU: | CAB8557 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-151 of human MYL6 (NP_066299.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HeLa, HepG2 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-151 of human MYL6 (NP_066299.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MCDF TEDQ TAEF KEAF QLFD RTGD GKIL YSQC GDVM RALG QNPT NAEV LKVL GNPK SDEM NVKV LDFE HFLP MLQT VAKN KDQG TYED YVEG LRVF DKEG NGTV MGAE IRHV LVTL GEKM TEEE VEML VAGH EDSN GCIN YEAF VRHI LSG |
| Gene ID: | 4637 |
| Uniprot: | P60660 |
| Cellular Location: | |
| Calculated MW: | 16kDa |
| Observed MW: | 14kDa |
| Synonyms: | MYL6, ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM |
| Background: | Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. |
| UniProt Protein Function: | MYL6: Regulatory light chain of myosin. Does not bind calcium. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 12q13.2 Cellular Component: brush border; cytosol; extracellular matrix; membrane; myosin complex; unconventional myosin complex; vesicle Molecular Function:actin-dependent ATPase activity; motor activity; protein binding; structural constituent of muscle Biological Process: muscle contraction; muscle filament sliding; skeletal muscle development |
| NCBI Summary: | Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P60660 |
| NCBI GenInfo Identifier: | 47606436 |
| NCBI Gene ID: | 4637 |
| NCBI Accession: | P60660.2 |
| UniProt Secondary Accession: | P60660,P16475, P24572, P24573, Q12790, Q561V9, Q6IAZ0 Q6IPY5, |
| UniProt Related Accession: | P60660 |
| Molecular Weight: | 17kDa |
| NCBI Full Name: | Myosin light polypeptide 6 |
| NCBI Synonym Full Names: | myosin light chain 6 |
| NCBI Official Symbol: | MYL6 |
| NCBI Official Synonym Symbols: | LC17; ESMLC; LC17A; LC17B; MLC-3; MLC1SM; MLC3NM; MLC3SM; LC17-GI; LC17-NM |
| NCBI Protein Information: | myosin light polypeptide 6 |
| UniProt Protein Name: | Myosin light polypeptide 6 |
| UniProt Synonym Protein Names: | 17 kDa myosin light chain; LC17; Myosin light chain 3; MLC-3; Myosin light chain alkali 3; Myosin light chain A3; Smooth muscle and nonmuscle myosin light chain alkali 6 |
| Protein Family: | Myosin light polypeptide |
| UniProt Gene Name: | MYL6 |
 | Western blot analysis of extracts of various cell lines, using MYL6 antibody (CAB8557) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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