| UniProt Protein Function: | MYH7B: Involved in muscle contraction. Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). 3 isoforms of the human protein are produced by alternative splicing.Protein type: Contractile; Motility/polarity/chemotaxis; MotorChromosomal Location of Human Ortholog: 20q11.22Cellular Component: membraneMolecular Function: protein binding; motor activity; actin binding; ATP bindingBiological Process: metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | The myosin II molecule is a multi-subunit complex consisting of two heavy chains and four light chains. This gene encodes a heavy chain of myosin II, which is a member of the motor-domain superfamily. The heavy chain includes a globular motor domain, which catalyzes ATP hydrolysis and interacts with actin, and a tail domain in which heptad repeat sequences promote dimerization by interacting to form a rod-like alpha-helical coiled coil. This heavy chain subunit is a slow-twitch myosin. Alternatively spliced transcript variants have been found, but the full-length nature of these variants is not determined. [provided by RefSeq, Mar 2010] |
| UniProt Code: | A7E2Y1 |
| NCBI GenInfo Identifier: | 153217512 |
| NCBI Gene ID: | 57644 |
| NCBI Accession: | AAI51243.1 |
| UniProt Secondary Accession: | A7E2Y1,Q5JVW7, Q6NT44, Q6NT57, Q6WG75, Q96I57, Q9NWE2 Q9P216 |
| UniProt Related Accession: | A7E2Y1 |
| Molecular Weight: | 20,273 Da |
| NCBI Full Name: | Myosin, heavy chain 7B, cardiac muscle, beta |
| NCBI Synonym Full Names: | myosin, heavy chain 7B, cardiac muscle, beta |
| NCBI Official Symbol: | MYH7B |
| NCBI Official Synonym Symbols: | MHC14; MYH14 |
| NCBI Protein Information: | myosin-7B |
| UniProt Protein Name: | Myosin-7B |
| UniProt Synonym Protein Names: | Antigen MLAA-21; Myosin cardiac muscle beta chain; Myosin heavy chain 7B, cardiac muscle beta isoform; Slow A MYH14 |
| Protein Family: | Myosin |
| UniProt Gene Name: | MYH7B |
| UniProt Entry Name: | MYH7B_HUMAN |
