Anti-MYH14 Antibody (CAB3690)
- SKU:
- CAB3690
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MYH14
- Synonyms:
- DFNA4
- Synonyms:
- DFNA4A
- Synonyms:
- FP17425
- Synonyms:
- MHC16
- Synonyms:
- MYH17
- Synonyms:
- NMHC II-C
- Synonyms:
- NMHC-II-C
- Synonyms:
- PNMHH
- Synonyms:
- myosin
- Synonyms:
- NMHCII-C
- Synonyms:
- myosin-14
Description
| Product Name: | MYH14 Rabbit pAb |
| Product Code: | CAB3690 |
| Size: | 100uL |
| Synonyms: | MYH14, DFNA4, DFNA4A, FP17425, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin, NMHCII-C, myosin-14 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human MYH14 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | A-431, HepG2, U-87MG, HT-29, 293T, A-549 |
| Immunogen: | A synthetic peptide of human MYH14 |
| Purification Method: | Affinity purification |
| Storage: | Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 79784 |
| Uniprot: | Q7Z406 |
| Calculated MW: | 167kDa/202kDa/227kDa/228kDa/232kDa |
| Observed MW: | 245kDa |
| UniProt Protein Function: | MYH14: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). High levels of expression are found in small intestine, colon and skeletal muscle. Expression is low in organs composed mainly of smooth muscle, such as aorta, uterus and urinary bladder. No detectable expression is found in thymus, spleen, placenta and lymphocytes. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Motor Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: actomyosin; axon; brush border; cytosol; growth cone; membrane; myelin sheath; myosin II complex; stress fiber Molecular Function:actin filament binding; actin-dependent ATPase activity; ATP binding; calmodulin binding; microfilament motor activity Biological Process: actin filament-based movement; actomyosin structure organization and biogenesis; axon guidance; ephrin receptor signaling pathway; generation of action potential; metabolic process; regulation of cell shape; sensory perception of sound; skeletal muscle contraction; skeletal muscle development; small GTPase mediated signal transduction Disease: Deafness, Autosomal Dominant 4a; Peripheral Neuropathy, Myopathy, Hoarseness, And Hearing Loss |
| NCBI Summary: | This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q7Z406 |
| NCBI GenInfo Identifier: | 327478526 |
| NCBI Gene ID: | 79784 |
| NCBI Accession: | Q7Z406.2 |
| UniProt Secondary Accession: | Q7Z406,Q5CZ75, Q6XYE4, Q76B62, Q8WV23, Q96I22, Q9BT27 Q9BW35, Q9H882, B0I1S2, C3TTN4, |
| UniProt Related Accession: | Q7Z406 |
| Molecular Weight: | |
| NCBI Full Name: | Myosin-14 |
| NCBI Synonym Full Names: | myosin, heavy chain 14, non-muscle |
| NCBI Official Symbol: | MYH14 |
| NCBI Official Synonym Symbols: | DFNA4; MHC16; MYH17; PNMHH; DFNA4A; myosin; FP17425; NMHC II-C; NMHC-II-C |
| NCBI Protein Information: | myosin-14 |
| UniProt Protein Name: | Myosin-14 |
| UniProt Synonym Protein Names: | Myosin heavy chain 14; Myosin heavy chain, non-muscle IIc; Non-muscle myosin heavy chain IIc; NMHC II-C |
| Protein Family: | Myosin |
| UniProt Gene Name: | MYH14 |
| UniProt Entry Name: | MYH14_HUMAN |
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