Anti-Myeloperoxidase (MPO) Antibody (CAB12109)
- SKU:
- CAB12109
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Product Name: | Myeloperoxidase (MPO) Rabbit mAb |
| Product Code: | CAB12109 |
| Size: | 20uL, 50uL, 100uL |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Myeloperoxidase (MPO) |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HL-60 |
| Immunogen: | A synthesized peptide derived from human Myeloperoxidase (MPO) |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4353 |
| Uniprot: | P05164 |
| Calculated MW: | 84kDa |
| Observed MW: | 13KDa |
| UniProt Protein Function: | MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.11.2.2; Oxidoreductase Chromosomal Location of Human Ortholog: 17q23.1 Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule Molecular Function:heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; defense response; response to yeast; response to lipopolysaccharide; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging Disease: Myeloperoxidase Deficiency; Alzheimer Disease |
| NCBI Summary: | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05164 |
| NCBI GenInfo Identifier: | 129825 |
| NCBI Gene ID: | 4353 |
| NCBI Accession: | P05164.1 |
| UniProt Secondary Accession: | P05164,Q14862, Q4PJH5, Q9UCL7, A1L4B8, |
| UniProt Related Accession: | P05164 |
| Molecular Weight: | 87,248 Da |
| NCBI Full Name: | Myeloperoxidase |
| NCBI Synonym Full Names: | myeloperoxidase |
| NCBI Official Symbol: | MPO |
| NCBI Protein Information: | myeloperoxidase |
| UniProt Protein Name: | Myeloperoxidase |
| Protein Family: | Myeloperoxidase |
| UniProt Gene Name: | MPO |
| UniProt Entry Name: | PERM_HUMAN |
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