Epigenetics & Nuclear Signaling Antibodies 1
Anti-MYC Antibody (CAB11394)
- SKU:
- CAB11394
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Antibody Name: | Anti-MYC Antibody |
Antibody SKU: | CAB11394 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | IHC |
Reactivity: | Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350 to the C-terminus of human MYC (NP_002458.2). |
Application: | IHC |
Recommended Dilution: | IHC 1:50 - 1:100 |
Reactivity: | Mouse, Rat |
Positive Samples: |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350 to the C-terminus of human MYC (NP_002458.2). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | QISN NRKC TSPR SSDT EENV KRRT HNVL ERQR RNEL KRSF FALR DQIP ELEN NEKA PKVV ILKK ATAY ILSV QAEE QKLI SEED LLRK RREQ LKHK LEQL RNSC A |
Gene ID: | 4609 |
Uniprot: | P01106 |
Cellular Location: | Nucleus, nucleolus, nucleoplasm |
Calculated MW: | 48kDa/50kDa |
Observed MW: |
Synonyms: | MRTL, MYCC, bHLHe39, c-Myc, MYC |
Background: | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. |
UniProt Protein Function: | Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes. |
UniProt Protein Details: | Protein type:DNA-binding; Nucleolus; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 8q24.21 Cellular Component: nucleoplasm; protein complex; nucleolus; nucleus; cytosol Molecular Function:protein dimerization activity; protein binding; DNA binding; protein complex binding; transcription factor binding; transcription factor activity Biological Process: oxygen transport; cellular iron ion homeostasis; positive regulation of transcription, DNA-dependent; positive regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin; chromosome organization and biogenesis; positive regulation of fibroblast proliferation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; response to gamma radiation; cell cycle arrest; response to drug; transcription initiation from RNA polymerase II promoter; Notch signaling pathway; regulation of telomere maintenance; transcription, DNA-dependent; MAPKKK cascade; negative regulation of cell division; negative regulation of stress-activated MAPK cascade; negative regulation of monocyte differentiation; chromatin remodeling; ureteric bud branching; regulation of gene expression; negative regulation of fibroblast proliferation; energy reserve metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus; positive regulation of epithelial cell proliferation; negative regulation of apoptosis Disease: Burkitt Lymphoma |
NCBI Summary: | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P01106 |
NCBI GenInfo Identifier: | 127619 |
NCBI Gene ID: | 4609 |
NCBI Accession: | P01106.1 |
UniProt Secondary Accession: | P01106,P01107, Q14026, A8WFE7, |
UniProt Related Accession: | P01106 |
Molecular Weight: | 439 |
NCBI Full Name: | Myc proto-oncogene protein |
NCBI Synonym Full Names: | v-myc avian myelocytomatosis viral oncogene homolog |
NCBI Official Symbol: | MYC |
NCBI Official Synonym Symbols: | MRTL; MYCC; c-Myc; bHLHe39 |
NCBI Protein Information: | myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor |
UniProt Protein Name: | Myc proto-oncogene protein |
UniProt Synonym Protein Names: | Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
Protein Family: | Myc protein |
UniProt Gene Name: | MYC |
UniProt Entry Name: | MYC_HUMAN |