Cell Biology Antibodies 12

Anti-MYBPC1 Antibody (CAB8348)

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SKU:
CAB8348
Product Type:
Antibody
Applications:
WB
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MYBPC1 Antibody
Antibody SKU:CAB8348
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 942-1171 of human MYBPC1 (NP_002456.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse skeletal muscle, Rat spinal cord
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 942-1171 of human MYBPC1 (NP_002456.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:PQIV KIED VWGE NVAL TWTP PKDD GNAA ITGY TIQK ADKK SMEW FTVI EHYH RTSA TITE LVIG NEYY FRVF SENM CGLS EDAT MTKE SAVI ARDG KIYK NPVY EDFD FSEA PMFT QPLV NTYA IAGY NATL NCSV RGNP KPKI TWMK NKVA IVDD PRYR MFSN QGVC TLEI RKPS PYDG GTYC CKAV NDLG TVEI ECKL EVKV IYQG VNTP GQPV FLEG QQQS LHNK DF
Gene ID:4604
Uniprot:Q00872
Cellular Location:
Calculated MW:126kDa/127kDa/128kDa/129kDa/131kDa
Observed MW:150kDa
Synonyms:MYBPC1, LCCS4, MYBPCC, MYBPCS, slow-type
Background:This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
NCBI Summary:This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q00872
NCBI GenInfo Identifier:6166597
NCBI Gene ID:4604
NCBI Accession:Q00872.2
UniProt Secondary Accession:Q00872,Q15497, Q17RR7, Q569K7, B4DKR5, B7Z8G8, B7ZL02 B7ZL09, B7ZL10, E7ESM5, E7EWS6, G3XAE8,
UniProt Related Accession:Q00872
Molecular Weight:129,074 Da
NCBI Full Name:Myosin-binding protein C, slow-type
NCBI Synonym Full Names:myosin binding protein C, slow type
NCBI Official Symbol:MYBPC1  
NCBI Official Synonym Symbols:LCCS4; MYBPCC; MYBPCS  
NCBI Protein Information:myosin-binding protein C, slow-type
UniProt Protein Name:Myosin-binding protein C, slow-type
UniProt Synonym Protein Names:C-protein, skeletal muscle slow isoform
Protein Family:Myosin-binding protein
UniProt Gene Name:MYBPC1  
UniProt Entry Name:MYPC1_HUMAN
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