Cell Biology Antibodies 9
Anti-MYBBP1A Antibody (CAB4429)
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- SKU:
- CAB4429
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MYBBP1A
- Synonyms:
- P160
- Synonyms:
- PAP2
- Synonyms:
- Pol5
- Research Area:
- Cell Biology
Description
| Product Name: | MYBBP1A Rabbit pAb |
| Product Code: | CAB4429 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | MYBBP1A, P160, PAP2, Pol5 |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A (NP_055335.2). |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, SW620, MCF7, Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A (NP_055335.2). |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DLTV LLGV LQGQ QQSL QQGA HSTG SSRL HDLY WQAM KTLG VQRP KLEK KDAK EIPS ATQS PISK KRKK KGFL PETK KRKK RKSE DGTP AEDG TPAA TGGS QPPS MGRK KRNR TKAK VPAQ ANGT PTTK SPAP GAPT RSPS TPAK SPKL QKKN QKPS QVNG APGS PTEP AGQK QHQK ALPK KGVL GKSP LSAL ARKK ARLS LVIR SPSL LQSG AKKK AQVR KAGK P |
| Gene ID: | 10514 |
| Uniprot: | Q9BQG0 |
| Cellular Location: | Cytoplasm, Nucleus, nucleolus |
| Calculated MW: | 148kDa/149kDa |
| Observed MW: | 149kDa |
| UniProt Protein Function: | MYBBP1A: may activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PGC-1 (PPAR gamma coactivator-1): this interaction is abrogated when PGC-1 is phosphorylated by ERK1. Binds to and stimulates transcription by AhR. Binds to KPNA2. Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on exportin 1. Predominantly nucleolar. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Nucleolus; DNA replication; DNA-binding; RNA-binding Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: NLS-dependent protein nuclear import complex; intracellular membrane-bound organelle; membrane; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; sequence-specific DNA binding; DNA-directed DNA polymerase activity; transcription corepressor activity; transcription factor binding Biological Process: osteoblast differentiation; cellular response to glucose starvation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleocytoplasmic transport; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q9BQG0 |
| NCBI GenInfo Identifier: | 71153825 |
| NCBI Gene ID: | 10514 |
| NCBI Accession: | Q9BQG0.2 |
| UniProt Secondary Accession: | Q9BQG0,Q86VM3, Q9BW49, Q9P0V5, Q9UF99, |
| UniProt Related Accession: | Q9BQG0 |
| Molecular Weight: | 1328 |
| NCBI Full Name: | Myb-binding protein 1A |
| NCBI Synonym Full Names: | MYB binding protein (P160) 1a |
| NCBI Official Symbol: | MYBBP1A |
| NCBI Official Synonym Symbols: | P160; PAP2 |
| NCBI Protein Information: | myb-binding protein 1A; p53-activated protein-2 |
| UniProt Protein Name: | Myb-binding protein 1A |
| Protein Family: | Myb-binding protein |
| UniProt Gene Name: | MYBBP1A |
| UniProt Entry Name: | MBB1A_HUMAN |
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