Epigenetics & Nuclear Signaling Antibodies 1
Anti-MYB Antibody (CAB13776)
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- SKU:
- CAB13776
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MYB Antibody |
| Antibody SKU: | CAB13776 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MYB (NP_005366.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MYB (NP_005366.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MARR PRHS IYSS DEDD EDFE MCDH DYDG LLPK SGKR HLGK TRWT REED EKLK KLVE QNGT DDWK VIAN YLPN RTDV QCQH RWQK VLNP ELIK GPWT KEED |
| Gene ID: | 4602 |
| Uniprot: | P10242 |
| Cellular Location: | Nucleus |
| Calculated MW: | 37-46kDa/63-85kDa |
| Observed MW: | Refer to figures |
| Synonyms: | MYB, Cmyb, c-myb, c-myb_CDS, efg |
| Background: | This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Myb: Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; Oncoprotein Chromosomal Location of Human Ortholog: 6q22-q23 Molecular Function:protein binding Biological Process: chromatin remodeling; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 methylation; positive regulation of T-helper cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P10242 |
| NCBI GenInfo Identifier: | 2815504 |
| NCBI Gene ID: | 4602 |
| NCBI Accession: | P10242.2 |
| UniProt Secondary Accession: | P10242,P78391, P78392, P78525, P78526, Q14023, Q14024 E9PI07, E9PLZ5, E9PNA4, E9PNL6, E9PRS2, |
| UniProt Related Accession: | P10242 |
| Molecular Weight: | 37,507 Da |
| NCBI Full Name: | Transcriptional activator Myb |
| NCBI Synonym Full Names: | MYB proto-oncogene, transcription factor |
| NCBI Official Symbol: | MYB |
| NCBI Official Synonym Symbols: | efg; Cmyb; c-myb; c-myb_CDS |
| NCBI Protein Information: | transcriptional activator Myb |
| UniProt Protein Name: | Transcriptional activator Myb |
| UniProt Synonym Protein Names: | Proto-oncogene c-Myb |
| Protein Family: | Myb protein |
| UniProt Gene Name: | MYB |
| UniProt Entry Name: | MYB_HUMAN |
 | Western blot analysis of extracts of MCF7 cells, using MYB antibody (CAB13776) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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