Epigenetics & Nuclear Signaling Antibodies 3

Anti-MXD3 Antibody (CAB14631)

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SKU:
CAB14631
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

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Antibody Name:Anti-MXD3 Antibody
Antibody SKU:CAB14631
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-170 of human MXD3 (NP_112590.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 30-170 of human MXD3 (NP_112590.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:ASLC PHRS PGPI HRRK KRPP QAPG AQDS GRSV HNEL EKRR RAQL KRCL ERLK QQMP LGAD CARY TTLS LLRR ARMH IQKL EDQE QRAR QLKE RLRS KQQS LQRQ LEQL RGLA GAAE RERL RADS LDSS GLSS ERSD SDQE E
Gene ID:83463
Uniprot:Q9BW11
Cellular Location:Nucleus
Calculated MW:22kDa/23kDa/42kDa
Observed MW:23kDa
Synonyms:MXD3, BHLHC13, MAD3, MYX
Background:This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.
UniProt Protein Function:MXD3: Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 5q35.3

Molecular Function:protein binding

NCBI Summary:This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]
UniProt Code:Q9BW11
NCBI GenInfo Identifier:74733390
NCBI Gene ID:83463
NCBI Accession:Q9BW11.1
UniProt Secondary Accession:Q9BW11,Q53HK1, Q7Z4Y0, Q8NDJ7, Q96ME3, B4E0J1,
UniProt Related Accession:Q9BW11
Molecular Weight:42,821 Da
NCBI Full Name:Max dimerization protein 3
NCBI Synonym Full Names:MAX dimerization protein 3
NCBI Official Symbol:MXD3  
NCBI Official Synonym Symbols:MYX; MAD3; BHLHC13  
NCBI Protein Information:max dimerization protein 3
UniProt Protein Name:Max dimerization protein 3
UniProt Synonym Protein Names:Class C basic helix-loop-helix protein 13; bHLHc13; Max-associated protein 3; Max-interacting transcriptional repressor MAD3; Myx
Protein Family:Max dimerization protein
UniProt Gene Name:MXD3  
UniProt Entry Name:MAD3_HUMAN
Anti-MXD3 Antibody (CAB14631)Western blot analysis of extracts of mouse brain, using MXD3 antibody (CAB14631) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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