Immunology Antibodies 2
Anti-MX1 Antibody (CAB1780)
- SKU:
- CAB1780
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-MX1 Antibody |
| Antibody SKU: | CAB1780 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 368-662 of human MX1 (NP_001171517.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, HeLa, A-549, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 368-662 of human MX1 (NP_001171517.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ENEK MFFL IDKV NAFN QDIT ALMQ GEET VGEE DIRL FTRL RHEF HKWS TIIE NNFQ EGHK ILSR KIQK FENQ YRGR ELPG FVNY RTFE TIVK QQIK ALEE PAVD MLHT VTDM VRLA FTDV SIKN FEEF FNLH RTAK SKIE DIRA EQER EGEK LIRL HFQM EQIV YCQD QVYR GALQ KVRE KELE EEKK KKSW DFGA FQSS SATD SSME EIFQ HLMA YHQE ASKR ISSH IPLI IQFF MLQT YGQQ LQKA MLQL LQDK DTYS WLLK ERSD TSDK RKFL KERL ARLT QARR RLAQ FPG |
| Gene ID: | 4599 |
| Uniprot: | P20591 |
| Cellular Location: | Cytoplasm, Cytoplasmic side, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein, perinuclear region |
| Calculated MW: | 55kDa/75kDa |
| Observed MW: | 78kDa |
| Synonyms: | MX1, IFI-78K, IFI78, MX, MxA |
| Background: | This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | MX1: Dynamin-like GTPase acting as a cell-autonomous host restriction factor against many viral pathogens. Shows activity against influenza viruses, rhabdovirus VSV, bunyavirus LACV, Thogoto virus, measles virus, Hantaan virus, Coxsackie virus CVB, Rift Valley fever virus RVFV, hepatitis B virus HBV, and Crimean- Congo hemorrhagic fever virus CCHFV. Belongs to the dynamin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Hydrolase; Apoptosis Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: endoplasmic reticulum membrane; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; cytosol Molecular Function:GTPase activity; protein binding; GTP binding Biological Process: negative regulation of viral genome replication; apoptosis; metabolic process; cytokine and chemokine mediated signaling pathway; response to virus; innate immune response; defense response; signal transduction; defense response to virus |
| NCBI Summary: | This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | P20591 |
| NCBI GenInfo Identifier: | 251757499 |
| NCBI Gene ID: | 4599 |
| NCBI Accession: | P20591.4 |
| UniProt Related Accession: | P20591 |
| Molecular Weight: | |
| NCBI Full Name: | Interferon-induced GTP-binding protein Mx1 |
| NCBI Synonym Full Names: | MX dynamin like GTPase 1 |
| NCBI Official Symbol: | MX1 |
| NCBI Official Synonym Symbols: | MX; MxA; IFI78; IFI-78K |
| NCBI Protein Information: | interferon-induced GTP-binding protein Mx1 |
| UniProt Protein Name: | Interferon-induced GTP-binding protein Mx1 |
| UniProt Synonym Protein Names: | Interferon-induced protein p78; IFI-78K; Interferon-regulated resistance GTP-binding protein MxA; Myxoma resistance protein 1; Myxovirus resistance protein 1Interferon-induced GTP-binding protein Mx1, N-terminally processed |
| Protein Family: | Interferon-induced GTP-binding protein |
| UniProt Gene Name: | MX1 |
| UniProt Entry Name: | MX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MX1 antibody (CAB1780) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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