Metabolism Antibodies 1

Anti-MVD Antibody (CAB15240)

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SKU:
CAB15240
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MVD Antibody
Antibody SKU:CAB15240
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MVD (NP_002452.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U-87MG, A-549, LO2, BxPC-3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human MVD (NP_002452.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASE KPLA AVTC TAPV NIAV IKYW GKRD EELV LPIN SSLS VTLH QDQL KTTT TAVI SKDF TEDR IWLN GREE DVGQ PRLQ ACLR EIRC LARK RRNS RDGD PLPS SLSC KVHV ASVN NFPT AAGL ASSA AGYA CLAY TLAR VYGV ESDL SEVA RRGS GSAC RSLY GGFV EWQM GEQA DGKD SIAR QVAP ESHW PELR VLIL VVSA EKKL TGST VGMR ASVE TSPL LRFR AESV VPAR MAEM ARCI RERD FPSF AQLT MKDS NQFH ATCL DT
Gene ID:4597
Uniprot:P53602
Cellular Location:
Calculated MW:43kDa
Observed MW:43kDa
Synonyms:MVD, FP17780, MDDase, MPD, POROK7
Background:The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP.
UniProt Protein Function:MVD: Performs the first committed step in the biosynthesis of isoprenes. Belongs to the diphosphomevalonate decarboxylase family.
UniProt Protein Details:

Protein type:Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Lyase; EC 4.1.1.33

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: cytosol; peroxisome

Molecular Function:diphosphomevalonate decarboxylase activity; Hsp70 protein binding; protein homodimerization activity

Biological Process: cholesterol biosynthetic process; dolichyl diphosphate biosynthetic process; isopentenyl diphosphate biosynthetic process, mevalonate pathway; isoprenoid biosynthetic process; positive regulation of cell proliferation

NCBI Summary:The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
UniProt Code:P53602
NCBI GenInfo Identifier:1706681
NCBI Gene ID:4597
NCBI Accession:P53602.1
UniProt Secondary Accession:P53602,Q53Y65,
UniProt Related Accession:P53602
Molecular Weight:43,405 Da
NCBI Full Name:Diphosphomevalonate decarboxylase
NCBI Synonym Full Names:mevalonate diphosphate decarboxylase
NCBI Official Symbol:MVD  
NCBI Official Synonym Symbols:MPD; MDDase; POROK7; FP17780  
NCBI Protein Information:diphosphomevalonate decarboxylase
UniProt Protein Name:Diphosphomevalonate decarboxylase
UniProt Synonym Protein Names:Mevalonate (diphospho)decarboxylase; MDDase; Mevalonate pyrophosphate decarboxylase
UniProt Gene Name:MVD  
UniProt Entry Name:MVD1_HUMAN
Anti-MVD Antibody (CAB15240)Western blot analysis of extracts of various cell lines, using MVD antibody (CAB15240) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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