Cell Biology Antibodies 6

Anti-MVB12A Antibody (CAB15930)

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SKU:
CAB15930
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MVB12A Antibody
Antibody SKU:CAB15930
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human MVB12A (NP_612410.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-273 of human MVB12A (NP_612410.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDPV PGTD SAPL AGLA WSSA SAPP PRGF SAIS CTVE GAPA SFGK SFAQ KSGY FLCL SSLG SLEN PQEN VVAD IQIV VDKS PLPL GFSP VCDP MDSK ASVS KKKR MCVK LLPL GATD TAVF DVRL SGKT KTVP GYLR IGDM GGFA IWCK KAKA PRPV PKPR GLSR DMQG LSLD AASQ PSKG GLLE RTAS RLGS RAST LRRN DSIY EASS LYGI SAMD GVPF TLHP RFEG KSCS PLAF SAFG DLTI KSLA DIEE EYNY GFVV EKTA AARL PPSV S
Gene ID:93343
Uniprot:Q96EY5
Cellular Location:Cytoplasm, Endosome, Late endosome membrane, Nucleus, Peripheral membrane protein, centrosome, cytoskeleton, microtubule organizing center
Calculated MW:24kDa/27kDa/28kDa
Observed MW:29kDa
Synonyms:MVB12A, CFBP, FAM125A
Background:
UniProt Protein Function:FAM125A: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down- regulation of EGF receptor. Belongs to the FAM125 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: centrosome; cytoplasm; cytosol; intracellular membrane-bound organelle; nucleoplasm; vesicle

Molecular Function:lipid binding; protein binding; ubiquitin binding

Biological Process: autophagy; positive regulation of viral reproduction; regulation of epidermal growth factor receptor signaling pathway; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; virus maturation

UniProt Code:Q96EY5
NCBI GenInfo Identifier:74731632
NCBI Gene ID:93343
NCBI Accession:Q96EY5.1
UniProt Secondary Accession:Q96EY5,Q96I18,
UniProt Related Accession:Q96EY5
Molecular Weight:28783 Da
NCBI Full Name:Multivesicular body subunit 12A
NCBI Synonym Full Names:multivesicular body subunit 12A
NCBI Official Symbol:MVB12A  
NCBI Official Synonym Symbols:CFBP; FAM125A  
NCBI Protein Information:multivesicular body subunit 12A
UniProt Protein Name:Multivesicular body subunit 12A
UniProt Synonym Protein Names:CIN85/CD2AP family-binding protein; ESCRT-I complex subunit MVB12A; Protein FAM125A
Protein Family:Multivesicular body
UniProt Gene Name:MVB12A  
UniProt Entry Name:MB12A_HUMAN
Anti-MVB12A Antibody (CAB15930)Western blot analysis of extracts of mouse liver, using MVB12A antibody (CAB15930) at 1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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