Epigenetics & Nuclear Signaling Antibodies 2
Anti-MUTYH Antibody (CAB1612)
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- SKU:
- CAB1612
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MUTYH Antibody |
| Antibody SKU: | CAB1612 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IHC IF |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human MUTYH (NP_001041636.1). |
| Application: | IHC IF |
| Recommended Dilution: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Rat |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-265 of human MUTYH (NP_001041636.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTPL VSRL SRLW AIMR KPRA AVGS GHRK QAAS QEGR QKHA KNNS QAKP SACD GLAR QPEE VVLQ ASVS SYHL FRDV AEVT AFRG SLLS WYDQ EKRD LPWR RRAE DEMD LDRR AYAV WVSE VMLQ QTQV ATVI NYYT GWMQ KWPT LQDL ASAS LEEV NQLW AGLG YYSR GRRL QEGA RKVV EELG GHMP RTAE TLQQ LLPG VGRY TAGA IASI AFGQ ATGV VDGN VARV LCRV RAIG ADPS STLV SQQL WGLA QQLV DPAR PGDF N |
| Gene ID: | 4595 |
| Uniprot: | Q9UIF7 |
| Cellular Location: | Nucleus |
| Calculated MW: | 57kDa/58kDa/59kDa/60kDa |
| Observed MW: |
| Synonyms: | MUTYH, MYH |
| Background: | This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7, 8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; DNA repair, damage; Tumor suppressor; Hydrolase; EC 3.2.2.- Chromosomal Location of Human Ortholog: 1p34.1 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA N-glycosylase activity; MutLalpha complex binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein binding Biological Process: depurination; DNA repair; mismatch repair Disease: Familial Adenomatous Polyposis, 2; Gastric Cancer; Pilomatrixoma |
| NCBI Summary: | This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UIF7 |
| NCBI GenInfo Identifier: | 48428272 |
| NCBI Gene ID: | 4595 |
| NCBI Accession: | Q9UIF7.1 |
| UniProt Secondary Accession: | Q9UIF7,Q15830, Q9UBP2, Q9UBS7, Q9UIF4, Q9UIF5, Q9UIF6 D3DPZ4, |
| UniProt Related Accession: | Q9UIF7 |
| Molecular Weight: | 57,446 Da |
| NCBI Full Name: | Adenine DNA glycosylase |
| NCBI Synonym Full Names: | mutY DNA glycosylase |
| NCBI Official Symbol: | MUTYH |
| NCBI Official Synonym Symbols: | MYH |
| NCBI Protein Information: | adenine DNA glycosylase |
| UniProt Protein Name: | Adenine DNA glycosylase |
| UniProt Synonym Protein Names: | MutY homolog; hMYH |
| UniProt Gene Name: | MUTYH |
| UniProt Entry Name: | MUTYH_HUMAN |
 | Immunofluorescence analysis of U2OS cells using MUTYH antibody (CAB1612). Blue: DAPI for nuclear staining. |
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