Cell Biology Antibodies 5
Anti-MUC2 Antibody (CAB14659)
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- SKU:
- CAB14659
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MUC2 Antibody |
| Antibody SKU: | CAB14659 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 4850-4950 of human MUC2 (NP_002448.4). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse stomach, Rat large intestine, Rat small intestine |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 4850-4950 of human MUC2 (NP_002448.4). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LCAQ QNIC LDWR NHTH GACL VECP SHRE YQAC GPAE EPTC KSSS SQQN NTVL VEGC FCPE GTMN YAPG FDVC VKTC GCVG PDNV PREF GEHF EFDC KNCV C |
| Gene ID: | 4583 |
| Uniprot: | Q02817 |
| Cellular Location: | Secreted |
| Calculated MW: | 540kDa |
| Observed MW: | 110kDa |
| Synonyms: | MUC2, MLP, MUC-2, SMUC, mucin-2 |
| Background: | This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. |
| UniProt Protein Function: | Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. |
| NCBI Summary: | This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016] |
| UniProt Code: | Q02817 |
| NCBI GenInfo Identifier: | 2506877 |
| NCBI Gene ID: | 4583 |
| NCBI Accession: | Q02817.2 |
| UniProt Secondary Accession: | Q02817,Q14878, |
| UniProt Related Accession: | Q02817 |
| Molecular Weight: | |
| NCBI Full Name: | Mucin-2 |
| NCBI Synonym Full Names: | mucin 2, oligomeric mucus/gel-forming |
| NCBI Official Symbol: | MUC2 |
| NCBI Official Synonym Symbols: | MLP; SMUC; MUC-2 |
| NCBI Protein Information: | mucin-2 |
| UniProt Protein Name: | Mucin-2 |
| UniProt Synonym Protein Names: | Intestinal mucin-2 |
| Protein Family: | Mucin |
| UniProt Gene Name: | MUC2 |
 | Western blot analysis of extracts of Mouse stomach, using MUC2 antibody (CAB14659) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Western blot analysis of extracts of various cell lines, using MUC2 antibody (CAB14659) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat ovary using MUC2 Rabbit pAb (CAB14659) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using MUC2 Rabbit pAb (CAB14659) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of Rat rectum using MUC2 Rabbit pAb (CAB14659) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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