Antibody Name:	Anti-MUC16 Antibody
Antibody SKU:	CAB10005
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 13965-14064 of human MUC16 (NP_078966.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 13965-14064 of human MUC16 (NP_078966.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	QRSS LGAR YTGC RVIA LRSV KNGA ETRV DLLC TYLQ PLSG PGLP IKQV FHEL SQQT HGIT RLGP YSLD KDSL YLNG YNEP GPDE PPTT PKPA TTFL PPLS
Gene ID:	94025
Uniprot:	Q8WXI7
Cellular Location:	Cell membrane, Secreted, Single-pass type I membrane protein, extracellular space
Calculated MW:	1519kDa
Observed MW:

Synonyms:

MUC16, CA125, mucin-16

Background:

This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.

UniProt Protein Function:	MUC16: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
UniProt Protein Details:	Protein type:Cell adhesion; Membrane protein, peripheral; Membrane protein, integral Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: extracellular space; extrinsic to membrane; Golgi lumen; plasma membrane; integral to membrane; vesicle Molecular Function:protein binding Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; cell adhesion; post-translational protein modification
UniProt Code:	Q8WXI7
NCBI GenInfo Identifier:	74716283
NCBI Gene ID:	94025
NCBI Accession:	Q8WXI7.2
UniProt Secondary Accession:	Q8WXI7,Q6ZQW5, Q96RK2,
UniProt Related Accession:	Q8WXI7
Molecular Weight:
NCBI Full Name:	Mucin-16
NCBI Synonym Full Names:	mucin 16, cell surface associated
NCBI Official Symbol:	MUC16
NCBI Official Synonym Symbols:	CA125
NCBI Protein Information:	mucin-16; CA125 ovarian cancer antigen; ovarian carcinoma antigen CA125; ovarian cancer-related tumor marker CA125
UniProt Protein Name:	Mucin-16
UniProt Synonym Protein Names:	Ovarian cancer-related tumor marker CA125; CA-125; Ovarian carcinoma antigen CA125
Protein Family:	Mucin
UniProt Gene Name:	MUC16
UniProt Entry Name:	MUC16_HUMAN

	Immunohistochemistry of paraffin-embedded mouse lung using MUC16 antibody (CAB10005) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human liver damage using MUC16 antibody (CAB10005) at dilution of 1:100 (40x lens).