Cell Biology Antibodies 7
Anti-MTTP Antibody (CAB1746)
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- SKU:
- CAB1746
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MTTP Antibody |
| Antibody SKU: | CAB1746 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human MTTP (NP_000244.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat small intestine |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human MTTP (NP_000244.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MILL AVLF LCFI SSYS ASVK GHTT GLSL NNDR LYKL TYST EVLL DRGK GKLQ DSVG YRIS SNVD VALL WRNP DGDD DQLI QITM KDVN VENV NQQR GEKS IFKG KSPS KIMG KENL EALQ RPTL LHLI HG |
| Gene ID: | 4547 |
| Uniprot: | P55157 |
| Cellular Location: | Endoplasmic reticulum |
| Calculated MW: | 16kDa/99kDa |
| Observed MW: | 99kDa |
| Synonyms: | MTTP, ABL, MTP |
| Background: | MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. |
| UniProt Protein Function: | MTTP: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. Defects in MTTP are the cause of abetalipoproteinemia (ABL). ABL is an autosomal recessive disorder of lipoprotein metabolism. Affected individuals produce virtually no circulating apolipoprotein B-containing lipoproteins (chylomicrons, VLDL, LDL, lipoprotein(A)). Malabsorption of the antioxidant vitamin E occurs, leading to spinocerebellar and retinal degeneration. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum Chromosomal Location of Human Ortholog: 4q24 Cellular Component: endoplasmic reticulum lumen; receptor complex Molecular Function:lipid transporter activity; lipid binding Biological Process: lipoprotein metabolic process; lipid metabolic process; lipid transport Disease: Abdominal Obesity-metabolic Syndrome 1; Abetalipoproteinemia |
| NCBI Summary: | MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P55157 |
| NCBI GenInfo Identifier: | 1709167 |
| NCBI Gene ID: | 4547 |
| NCBI Accession: | P55157.1 |
| UniProt Secondary Accession: | P55157,Q08AM4, Q6P5T3, A8K428, |
| UniProt Related Accession: | P55157 |
| Molecular Weight: | 894 |
| NCBI Full Name: | Microsomal triglyceride transfer protein large subunit |
| NCBI Synonym Full Names: | microsomal triglyceride transfer protein |
| NCBI Official Symbol: | MTTP |
| NCBI Official Synonym Symbols: | ABL; MTP |
| NCBI Protein Information: | microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein (large polypeptide, 88kDa) |
| UniProt Protein Name: | Microsomal triglyceride transfer protein large subunit |
| Protein Family: | Microsomal triglyceride transfer protein |
| UniProt Gene Name: | MTTP |
| UniProt Entry Name: | MTP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTTP antibody (CAB1746) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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