Metabolism Antibodies 1
Anti-MTRR Antibody (CAB1462)
- SKU:
- CAB1462
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-MTRR Antibody |
| Antibody SKU: | CAB1462 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-230 of human MTRR (NP_002445.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | A-549, HeLa, LO2, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-230 of human MTRR (NP_002445.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | TAPL VVVV STTG TGDP PDTA RKFV KEIQ NQTL PVDF FAHL RYGL LGLG DSEY TYFC NGGK IIDK RLQE LGAR HFYD TGHA DDCV GLEL VVEP WIAG LWPA LRKH FRSS RGQE EISG ALPV ASPA SSRT DLVK SELL HIES QVEL LRFD DSGR KDSE VLKQ NAVN SNQS NVVI EDFE SSLT R |
| Gene ID: | 4552 |
| Uniprot: | Q9UBK8 |
| Cellular Location: | Cytoplasm, Cytoplasm |
| Calculated MW: | 6kDa/77kDa/80kDa |
| Observed MW: | 80kDa |
| Synonyms: | MTRR, MSR, cblE |
| Background: | This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. |
| NCBI Summary: | This gene encodes a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. This protein functions in the synthesis of methionine by regenerating methionine synthase to a functional state. Because methionine synthesis requires methyl-group transfer by a folate donor, activity of the encoded enzyme is important for folate metabolism and cellular methylation. Mutations in this gene can cause homocystinuria-megaloblastic anemia, cbl E type. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q9UBK8 |
| NCBI GenInfo Identifier: | 169790958 |
| NCBI Gene ID: | 4552 |
| NCBI Accession: | NP_002445 |
| UniProt Related Accession: | Q9UBK8 |
| Molecular Weight: | |
| NCBI Full Name: | methionine synthase reductase |
| NCBI Synonym Full Names: | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
| NCBI Official Symbol: | MTRR |
| NCBI Official Synonym Symbols: | MSR; cblE |
| NCBI Protein Information: | methionine synthase reductase |
| UniProt Protein Name: | Methionine synthase reductase |
| Protein Family: | Mycothione reductase |
| UniProt Gene Name: | MTRR |
| UniProt Entry Name: | MTRR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTRR antibody (CAB1462) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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