Cell Biology Antibodies 13

Anti-MTPAP Antibody (CAB17715)

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SKU:
CAB17715
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MTPAP Antibody
Antibody SKU:CAB17715
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-87MG, U-251MG, Jurkat, Mouse spleen
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MVIF FLQR RSPP ILPT LDSL KTLA DAED KCVI EGNN CTFV RDLS RIKP SQNT ETLE LLLK EFFE YFGN FAFD KNSI NIRQ GREQ NKPD SSPL YIQN PFET SLNI SKNV SQSQ LQKF VDLA RESA WILQ QEDT DRPS ISSN RPWG LVSL LLPS APNR KSFT KKKS NKFA IETV KNLL ESLK GNRT ENFT KTSG KRTI STQT
Gene ID:55149
Uniprot:Q9NVV4
Cellular Location:
Calculated MW:
Observed MW:60kDa
Anti-MTPAP Antibody (CAB17715)Western blot - MTPAP Polyclonal Antibody (CAB17715)
Synonyms:PAPD1, SPAX4, MTPAP
Background:The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]
UniProt Protein Function:PAPD1: Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. Defects in MTPAP are the cause of spastic ataxia autosomal recessive type 4 (SPAX4). A slowly progressive neurodegenerative disease characterized by cerebellar ataxia, spastic paraparesis, dysarthria, and optic atrophy. Affected individuals exhibit a drastic decrease in poly(A) tail length of representative mitochondrial mRNA transcripts, including COX1 and RNA14 (PubMed:20970105). Belongs to the DNA polymerase type-B-like family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.7.7.19; RNA processing; Transferase

Chromosomal Location of Human Ortholog: 10p11.23

Cellular Component: mitochondrion; intracellular membrane-bound organelle

Molecular Function:polynucleotide adenylyltransferase activity; identical protein binding; protein binding; protein homodimerization activity; manganese ion binding; magnesium ion binding; ATP binding

Biological Process: transcription, DNA-dependent; mRNA polyadenylation

Disease: Spastic Ataxia 4, Autosomal Recessive

NCBI Summary:The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.[provided by RefSeq, Jan 2011]
UniProt Code:Q9NVV4
NCBI GenInfo Identifier:74753002
NCBI Gene ID:55149
NCBI Accession:Q9NVV4.1
UniProt Related Accession:Q9NVV4
Molecular Weight:
NCBI Full Name:Poly(A) RNA polymerase, mitochondrial
NCBI Synonym Full Names:mitochondrial poly(A) polymerase
NCBI Official Symbol:MTPAP  
NCBI Official Synonym Symbols:PAPD1; SPAX4; TENT6  
NCBI Protein Information:poly(A) RNA polymerase, mitochondrial
UniProt Protein Name:Poly(A) RNA polymerase, mitochondrial
UniProt Synonym Protein Names:PAP-associated domain-containing protein 1; Polynucleotide adenylyltransferase; Terminal uridylyltransferase 1; TUTase 1; mtPAP
Protein Family:Poly(A) RNA polymerase
UniProt Gene Name:MTPAP  
UniProt Entry Name:PAPD1_HUMAN
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