Epigenetics & Nuclear Signaling Antibodies 4
Anti-MTO1 Antibody (CAB9121)
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- SKU:
- CAB9121
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MTO1 Antibody |
| Antibody SKU: | CAB9121 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-680 of human MTO1 (NP_036255.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Raji, HeLa, MCF7, Mouse kidney, Mouse heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-680 of human MTO1 (NP_036255.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QGVI AGIN ASLR VSRK PPFV VSRT EGYI GVLI DDLT TLGT SEPY RMFT SRVE FRLS LRPD NADS RLTL RGYK DAGC VSQQ RYER ACWM KSSL EEGI SVLK SIEF LSSK WKKL IPEA SIST SRSL PVRA LDVL KYEE VDMD SLAK AVPE PLKK YTKC RELA ERLK IEAT YESV LFHQ LQEI KGVQ QDEA LQLP KDLD YLTI RDVS LSHE VREK LHFS RPQT IGAA SRIP GVTP AAII NLLR FVKT TQRR QSAM NESS KTDQ Y |
| Gene ID: | 25821 |
| Uniprot: | Q9Y2Z2 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 34kDa/66kDa/72kDa/77kDa/79kDa/81kDa |
| Observed MW: | 80kDa |
| Synonyms: | MTO1, CGI-02, COXPD10 |
| Background: | This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | MTO1: Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Defects in MTO1 are the cause of combined oxidative phosphorylation deficiency type 10 (COXPD10). An autosomal recessive disorder resulting in variable defects of mitochondrial oxidative respiration. Affected individuals present in infancy with hypertrophic cardiomyopathy and lactic acidosis. The severity is variable, but can be fatal in the most severe cases. Belongs to the MnmG family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA processing Chromosomal Location of Human Ortholog: 6q13 Cellular Component: mitochondrion Molecular Function:FAD binding Disease: Combined Oxidative Phosphorylation Deficiency 10 |
| NCBI Summary: | This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2Z2 |
| NCBI GenInfo Identifier: | 183227703 |
| NCBI Gene ID: | 25821 |
| NCBI Accession: | NP_001116698.1 |
| UniProt Secondary Accession: | Q9Y2Z2,Q5SWL2, Q5SWL3, Q5SWL4, Q8NDN7, Q8WZ57, Q96FE6 Q9BS06, B3KQB5, |
| Molecular Weight: | 81,538 Da |
| NCBI Full Name: | protein MTO1 homolog, mitochondrial isoform c |
| UniProt Protein Name: | Protein MTO1 homolog, mitochondrial |
| Protein Family: | Mitochondrial translation optimization protein |
| UniProt Gene Name: | MTO1 |
| UniProt Entry Name: | MTO1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTO1 antibody (CAB9121) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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