Cell Biology Antibodies 6
Anti-MTMR6 Antibody (CAB15348)
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- SKU:
- CAB15348
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MTMR6 Antibody |
| Antibody SKU: | CAB15348 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_004676.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, HeLa, 293T, Mouse heart, Mouse brain, Mouse lung, Mouse spleen, Mouse testis, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_004676.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RCGQ LDGD PKEV SPVF TQFL ECVW HLTE QFPQ AFEF SEAF LLQI HEHI HSCQ FGNF LGNC QKER EELK LKEK TYSL WPFL LEDQ KKYL NPLY SSES HRFT VLEP NTVS FNFK FWRN MYHQ FDRT LHPR QSVF NIIM NMNE QNKQ LEKD IKDL ESKI KQRK NKQT DGIL TKEL LHSV HPES PNLK TSLC FKEQ TLLP VNDA LRTI EGSS PADN RYSE YAEE FSKS EPAV VSLE YGVA RMTC |
| Gene ID: | 9107 |
| Uniprot: | Q9Y217 |
| Cellular Location: | Nucleus envelope |
| Calculated MW: | 63kDa/71kDa |
| Observed MW: | 72kDa |
| Synonyms: | MTMR6 |
| Background: |
| UniProt Protein Function: | MTMR6: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.-; Cofactor and Vitamin Metabolism - riboflavin; Phosphatase, lipid; Cofactor and Vitamin Metabolism - thiamine; Carbohydrate Metabolism - fructose and mannose Chromosomal Location of Human Ortholog: 13q12 Cellular Component: cytoplasm; cytosol Molecular Function:calcium-activated potassium channel activity; phosphatidylinositol-3-phosphatase activity; protein binding Biological Process: phosphatidylinositol biosynthetic process |
| UniProt Code: | Q9Y217 |
| NCBI GenInfo Identifier: | 317373414 |
| NCBI Gene ID: | 9107 |
| NCBI Accession: | Q9Y217.3 |
| UniProt Secondary Accession: | Q9Y217,Q5JRG6, Q86TB7, Q86YH4, Q96P80, B2RBB5, B3KSB4 |
| UniProt Related Accession: | Q9Y217 |
| Molecular Weight: | 63,743 Da |
| NCBI Full Name: | Myotubularin-related protein 6 |
| NCBI Synonym Full Names: | myotubularin related protein 6 |
| NCBI Official Symbol: | MTMR6 |
| NCBI Protein Information: | myotubularin-related protein 6 |
| UniProt Protein Name: | Myotubularin-related protein 6 |
| Protein Family: | Myotubularin-related protein |
| UniProt Gene Name: | MTMR6 |
| UniProt Entry Name: | MTMR6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTMR6 antibody (CAB15348) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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