Cell Biology Antibodies 6
Anti-MTMR4 Antibody (CAB15349)
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- SKU:
- CAB15349
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MTMR4 Antibody |
| Antibody SKU: | CAB15349 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 920-1195 of human MTMR4 (NP_004678.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:200 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, HepG2, Mouse brain, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 920-1195 of human MTMR4 (NP_004678.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GEAT PRRL LSYG CCSK RPNS KQMR ATGP CFGG QWAQ REGV KSPV CSSH SNGH CTGP GGKN QMWL SSHP KQVS STKP VPLN CPSP VPPL YLDD DGLP FPTD VIQH RLRQ IEAG YKQE VEQL RRQV RELQ MRLD IRHC CAPP AEPP MDYE DDFT CLKE SDGS DTED FGSD HSED CLSE ASWE PVDK KETE VTRW VPDH MASH CYNC DCEF WLAK RRHH CRNC GNVF CAGC CHLK LPIP DQQL YDPV LVCN SCYE HIQV SRAR ELMS QQLK KPIA TASS |
| Gene ID: | 9110 |
| Uniprot: | Q9NYA4 |
| Cellular Location: | Cytoplasm, Membrane, Peripheral membrane protein |
| Calculated MW: | 133kDa |
| Observed MW: | 133kDa |
| Synonyms: | MTMR4, FYVE-DSP2, ZFYVE11 |
| Background: |
| UniProt Protein Function: | MTMR4: Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3). Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor); Protein phosphatase, dual-specificity Chromosomal Location of Human Ortholog: 17q22 Cellular Component: cytosol; early endosome membrane; extracellular space Molecular Function:phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway; phosphatidylinositol biosynthetic process; protein amino acid dephosphorylation |
| UniProt Code: | Q9NYA4 |
| NCBI GenInfo Identifier: | 296438298 |
| NCBI Gene ID: | 9110 |
| NCBI Accession: | Q9NYA4.2 |
| UniProt Secondary Accession: | Q9NYA4,Q8IV27, Q9Y4D5, D3DTZ6, |
| UniProt Related Accession: | Q9NYA4 |
| Molecular Weight: | 133,353 Da |
| NCBI Full Name: | Myotubularin-related protein 4 |
| NCBI Synonym Full Names: | myotubularin related protein 4 |
| NCBI Official Symbol: | MTMR4 |
| NCBI Official Synonym Symbols: | ZFYVE11; FYVE-DSP2 |
| NCBI Protein Information: | myotubularin-related protein 4 |
| UniProt Protein Name: | Myotubularin-related protein 4 |
| UniProt Synonym Protein Names: | FYVE domain-containing dual specificity protein phosphatase 2; FYVE-DSP2; Zinc finger FYVE domain-containing protein 11 |
| Protein Family: | Myotubularin-related protein |
| UniProt Gene Name: | MTMR4 |
| UniProt Entry Name: | MTMR4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTMR4 antibody (CAB15349) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunofluorescence analysis of L929 cells using MTMR4 Polyclonal Antibody (CAB15349) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U-2 OS cells using MTMR4 Polyclonal Antibody (CAB15349) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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