Metabolism Antibodies 1

Anti-MTMR3 Antibody (CAB10806)

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SKU:
CAB10806
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-MTMR3 Antibody
Antibody SKU:CAB10806
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse
Positive Samples:U-87MG, HeLa, Jurkat, LO2
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:KWQE HRRS LELS SLAG PGED PLSA DSLG KPTR VPGG AELS VAAG VAEG QMEN ILQE ATKE ESGV EEPA HRAG IEIQ EGKE DPLL EKES RRKT PEAS AIGL HQDP ELGD AALR SHLD MSWP LFSQ GISE QQSG LSVL LSSL QVPP RGED SLEV PVEQ FRIE EIAE GREE AVL
Gene ID:8897
Uniprot:Q13615
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:129kDa/130kDa/133kDa
Observed MW:134kDa
Synonyms:MTMR3, FYVE-DSP1, ZFYVE10
Background:This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3, 5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:MTMR3: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.3.48; EC 3.1.3.64; EC 3.1.3.95; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: cytoplasm; cytosol; extrinsic to membrane; membrane

Molecular Function:phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: cellular response to glucose starvation; macroautophagy; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation

NCBI Summary:This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q13615
NCBI GenInfo Identifier:33112668
NCBI Gene ID:8897
NCBI Accession:Q13615.3
UniProt Secondary Accession:Q13615,Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3, A5PL26, A7MD32
UniProt Related Accession:Q13615
Molecular Weight:134kDa
NCBI Full Name:Myotubularin-related protein 3
NCBI Synonym Full Names:myotubularin related protein 3
NCBI Official Symbol:MTMR3  
NCBI Official Synonym Symbols:ZFYVE10; FYVE-DSP1  
NCBI Protein Information:myotubularin-related protein 3
UniProt Protein Name:Myotubularin-related protein 3
UniProt Synonym Protein Names:FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95
UniProt Gene Name:MTMR3  
Anti-MTMR3 Antibody (CAB10806)Western blot analysis of extracts of various cell lines, using MTMR3 antibody (CAB10806) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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