Cell Biology Antibodies 17

Anti-MTH1 Antibody (CAB3938)

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SKU:
CAB3938
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MTH1 Antibody
Antibody SKU:CAB3938
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MTH1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:U2OS, MCF7, Jurkat
Immunogen:A synthesized peptide derived from human MTH1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4521
Uniprot:P36639
Cellular Location:
Calculated MW:18kDa
Observed MW:18KDa
Synonyms:MTH1
Background:Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
UniProt Protein Function:NUDT1: Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Belongs to the Nudix hydrolase family. 4 isoforms of the human protein are produced by alternative initiation.
UniProt Protein Details:

Protein type:EC 3.6.1.55; Hydrolase; EC 3.6.1.56

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; nucleus; cytosol

Molecular Function:GTPase activity; snoRNA binding; m7G(5')pppN diphosphatase activity; metal ion binding; ATP diphosphatase activity; 8-oxo-7,8-dihydroguanine triphosphatase activity

Biological Process: DNA protection; dGTP catabolic process; nucleobase, nucleoside and nucleotide metabolic process; dATP catabolic process; purine nucleotide catabolic process; response to oxidative stress; DNA repair

NCBI Summary:Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
UniProt Code:P36639
NCBI GenInfo Identifier:254763430
NCBI Gene ID:4521
NCBI Accession:P36639.3
UniProt Secondary Accession:P36639,Q6LES7, Q6P0Y6, Q7Z7N6, Q8IV95, Q9UBM0, Q9UBM9 A4D205,
UniProt Related Accession:P36639
Molecular Weight:197
NCBI Full Name:7,8-dihydro-8-oxoguanine triphosphatase
NCBI Synonym Full Names:nudix (nucleoside diphosphate linked moiety X)-type motif 1
NCBI Official Symbol:NUDT1  
NCBI Official Synonym Symbols:MTH1  
NCBI Protein Information:7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; nudix motif 1; mutT human homolog 1; 2-hydroxy-dATP diphosphatase; 8-oxo-7,8-dihydroguanosine triphosphatase; 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase; nucleoside diphosphate-linked moiety X motif 1; nucleoside diphosphate-linked moiety X-type motif 1
UniProt Protein Name:7,8-dihydro-8-oxoguanine triphosphatase
UniProt Synonym Protein Names:2-hydroxy-dATP diphosphatase (EC:3.6.1.56); 8-oxo-dGTPase; Nucleoside diphosphate-linked moiety X motif 1; Nudix motif 1
Protein Family:Nudix hydrolase
UniProt Gene Name:NUDT1  
UniProt Entry Name:8ODP_HUMAN
Anti-MTH1 Antibody (CAB3938)Western blot - MTH1 Rabbit mAb (CAB3938)
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