Cell Death Antibodies 2
Anti-MTFP1 Antibody (CAB7110)
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- SKU:
- CAB7110
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
| Antibody Name: | Anti-MTFP1 Antibody |
| Antibody SKU: | CAB7110 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human MTFP1 (NP_057582.2). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse heart, Rat liver, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human MTFP1 (NP_057582.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MSEP QPRG AERD LYRD TWVR YLGY ANEV GEAF RSLV PAAV VWLS YGVA SSYV LADA IDKG KKAG EVPS PEAG RSAR VTVA VVDT FVWQ ALAS VAIP GFTI NRVC AASL YVLG TATR WPLA VRKW TTTA LGLL TIPI IIHP IDRS VDFL LDSS LRKL YPTV GKPS SS |
| Gene ID: | 51537 |
| Uniprot: | Q9UDX5 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 14kDa/18kDa |
| Observed MW: | 25kDa |
| Synonyms: | MTFP1, HSPC242, MTP18 |
| Background: |
| UniProt Protein Function: | MTP18: Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the caspase cascade and leads to apoptosis. Belongs to the MTFP1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 22q Cellular Component: mitochondrial inner membrane; integral to membrane Biological Process: mitochondrial fission; apoptosis |
| NCBI Summary: | MTP18 is a mitochondrial protein and downstream target of the phosphatidylinositol 3-kinase (see PIK3CA, MIM 171834) signaling pathway that plays a role in cell viability and mitochondrial dynamics (Tondera et al., 2004 [PubMed 15155745]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9UDX5 |
| NCBI GenInfo Identifier: | 52783151 |
| NCBI Gene ID: | 51537 |
| NCBI Accession: | Q9UDX5.1 |
| UniProt Secondary Accession: | Q9UDX5,Q9H3K1, Q9P0N6, A6NFQ5, |
| UniProt Related Accession: | Q9UDX5 |
| Molecular Weight: | 166 |
| NCBI Full Name: | Mitochondrial fission process protein 1 |
| NCBI Synonym Full Names: | mitochondrial fission process 1 |
| NCBI Official Symbol: | MTFP1 |
| NCBI Official Synonym Symbols: | MTP18; HSPC242 |
| NCBI Protein Information: | mitochondrial fission process protein 1; mitochondrial 18 kDa protein; mitochondrial protein 18 kDa; mitochondrial fission protein MTP18 |
| UniProt Protein Name: | Mitochondrial fission process protein 1 |
| UniProt Synonym Protein Names: | Mitochondrial 18 kDa protein; MTP18 |
| Protein Family: | Mitochondrial fission process protein |
| UniProt Gene Name: | MTFP1 |
| UniProt Entry Name: | MTFP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MTFP1 antibody (CAB7110) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using MTFP1 antibody (CAB7110) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using MTFP1 antibody (CAB7110) at dilution of 1:100 (40x lens). |
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