Cell Biology Antibodies 15
Anti-MT-CO2 Antibody (CAB17965)
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- SKU:
- CAB17965
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MT-CO2 Antibody |
| Antibody SKU: | CAB17965 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human MT-CO2 |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | mouse brain, mouse liver, mouse heart |
| Immunogen: | A synthetic peptide of human MT-CO2 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4513 |
| Uniprot: | P00403 |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
| Calculated MW: | 25kDa |
| Observed MW: | 20kDa |
 | Western blot - MT-CO2 Polyclonal Antibody (CAB17965) |
| Synonyms: | MT-CO2, COII, MTCO2, COX2 |
| Background: |
| UniProt Protein Function: | COX2: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the cytochrome c oxidase subunit 2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; Energy Metabolism - oxidative phosphorylation; Mitochondrial; EC 1.9.3.1 Chromosomal Location of Human Ortholog: - Disease: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes |
| UniProt Code: | P00403 |
| NCBI GenInfo Identifier: | 117020 |
| NCBI Gene ID: | |
| NCBI Accession: | P00403.1 |
| Molecular Weight: | |
| NCBI Full Name: | Cytochrome c oxidase subunit 2 |
| UniProt Protein Name: | Cytochrome c oxidase subunit 2 |
| UniProt Synonym Protein Names: | Cytochrome c oxidase polypeptide II |
| UniProt Gene Name: | MT-CO2 |
| UniProt Entry Name: | COX2_HUMAN |
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