Cell Biology Antibodies 8

Anti-MSX2 Antibody (CAB2017)

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SKU:
CAB2017
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MSX2 Antibody
Antibody SKU:CAB2017
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-267 of human MSX2 (NP_002440.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, NIH/3T3, C2C12, mouse spinal cord, rat brain, rat uterus
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-267 of human MSX2 (NP_002440.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASP SKGN DLFS PDEE GPAV VAGP GPGP GGAE GAAE ERRV KVSS LPFS VEAL MSDK KPPK EASP LPAE SASA GATL RPLL LSGH GARE AHSP GPLV KPFE TASV KSEN SEDG AAWM QEPG RYSP PPRH MSPT TCTL RKHK TNRK PRTP FTTS QLLA LERK FRQK QYLS IAER AEFS SSLN LTET QVKI WFQN RRAK AKRL QEAE LEKL KMAA KPML PSSF SLPF PISS PLQA ASIY GASY PFHR PVLP IPPV GLYA TPVG YGMY HLS
Gene ID:4488
Uniprot:P35548
Cellular Location:Nucleus
Calculated MW:28kDa
Observed MW:29kDa
Synonyms:MSX2, CRS2, FPP, HOX8, MSH, PFM, PFM1
Background:This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.
UniProt Protein Function:MSX2: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. Defects in MSX2 are the cause of parietal foramina 1 (PFM1); also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD); also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles. Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2); also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominant disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal. Belongs to the Msh homeobox family.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 5q35.2

Molecular Function:protein binding; sequence-specific DNA binding; transcription cofactor activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; osteoblast differentiation

Disease: Craniosynostosis 2; Parietal Foramina; Parietal Foramina With Cleidocranial Dysplasia

NCBI Summary:This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]
UniProt Code:P35548
NCBI GenInfo Identifier:311033429
NCBI Gene ID:4488
NCBI Accession:P35548.3
UniProt Secondary Accession:P35548,Q53XM4, Q9UD60, D3DQN1,
UniProt Related Accession:P35548
Molecular Weight:28,897 Da
NCBI Full Name:Homeobox protein MSX-2
NCBI Synonym Full Names:msh homeobox 2
NCBI Official Symbol:MSX2  
NCBI Official Synonym Symbols:FPP; MSH; PFM; CRS2; HOX8; PFM1  
NCBI Protein Information:homeobox protein MSX-2
UniProt Protein Name:Homeobox protein MSX-2
UniProt Synonym Protein Names:Homeobox protein Hox-8
Protein Family:Msx2-interacting protein
UniProt Gene Name:MSX2  
UniProt Entry Name:MSX2_HUMAN
Anti-MSX2 Antibody (CAB2017)Western blot analysis of extracts of various cell lines, using MSX2 antibody (CAB2017) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s.
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