Cell Biology Antibodies 18

Anti-MSX1 Antibody (CAB18295)

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SKU:
CAB18295
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MSX1 Antibody
Antibody SKU:CAB18295
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human MSX1.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant protein of human MSX1.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4487
Uniprot:P28360
Cellular Location:
Calculated MW:31kDa
Observed MW:Refer to figures
Synonyms:HOX7, HYD1, ECTD3, STHAG1, MSX1
Background:This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.
UniProt Protein Function:MSX1: Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity. Expressed in the developing nail bed mesenchyme. Belongs to the Msh homeobox family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 4p16.2

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function:p53 binding

Biological Process: cell morphogenesis; negative regulation of cell growth; odontogenesis of dentine-containing teeth; positive regulation of DNA damage response, signal transduction by p53 class mediator; protein stabilization

Disease: Orofacial Cleft 5; Tooth Agenesis, Selective, 1; Witkop Syndrome

NCBI Summary:This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in this gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia. [provided by RefSeq, Jul 2008]
UniProt Code:P28360
NCBI GenInfo Identifier:557952603
NCBI Gene ID:4487
NCBI Accession:P28360.3
UniProt Secondary Accession:P28360,Q96NY4, A0SZU5, A8K3M1,
UniProt Related Accession:P28360
Molecular Weight:31,496 Da
NCBI Full Name:Homeobox protein MSX-1
NCBI Synonym Full Names:msh homeobox 1
NCBI Official Symbol:MSX1  
NCBI Official Synonym Symbols:HOX7; HYD1; ECTD3; STHAG1  
NCBI Protein Information:homeobox protein MSX-1
UniProt Protein Name:Homeobox protein MSX-1
UniProt Synonym Protein Names:Homeobox protein Hox-7; Msh homeobox 1-like protein
Protein Family:Homeobox protein
UniProt Gene Name:MSX1  
UniProt Entry Name:MSX1_HUMAN
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