Immunology Antibodies 1

Anti-MST1R Antibody (CAB0590)

(No reviews yet) Write a Review
SKU:
CAB0590
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MST1R Antibody
Antibody SKU:CAB0590
Antibody Size:20uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide of human MST1R
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse lung
Immunogen:A synthetic peptide of human MST1R
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4486
Uniprot:Q04912
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:52kDa/57kDa/69kDa/97kDa/147kDa/152kDa
Observed MW:145kDa
Synonyms:MST1R, CD136, CDw136, NPCA3, PTK8, RON
Background:This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing.
UniProt Protein Function:Ron: a receptor tyrosine kinase of the Met family. Receptor for macrophage stimulating protein. Can be desensitized by c-Cbl and its binding partner Grb2. Overexpression of wild-type RON causes the formation of lung tumors. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; TK group; Met family

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: cell surface; integral to plasma membrane; stress fiber; vacuole

Molecular Function:ATP binding; enzyme binding; macrophage colony stimulating factor receptor activity; protein binding

Biological Process: cell motility; defense response; innate immune response; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; response to virus; signal transduction; single fertilization; transmembrane receptor protein tyrosine kinase signaling pathway

NCBI Summary:This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]
UniProt Code:Q04912
NCBI GenInfo Identifier:294862462
NCBI Gene ID:4486
NCBI Accession:Q04912.2
UniProt Secondary Accession:Q04912,B5A944, B5A945, B5A946, B5A947,
UniProt Related Accession:Q04912
Molecular Weight:69,265 Da
NCBI Full Name:Macrophage-stimulating protein receptor
NCBI Synonym Full Names:macrophage stimulating 1 receptor
NCBI Official Symbol:MST1R  
NCBI Official Synonym Symbols:RON; PTK8; CD136; CDw136  
NCBI Protein Information:macrophage-stimulating protein receptor
UniProt Protein Name:Macrophage-stimulating protein receptor
UniProt Synonym Protein Names:CDw136; Protein-tyrosine kinase 8; p185-Ron; CD_antigen: CD136
Protein Family:Macrophage-stimulating protein receptor
UniProt Gene Name:MST1R  
UniProt Entry Name:RON_HUMAN
Anti-MST1R Antibody (CAB0590)Western blot analysis of extracts of mouse lung, using MST1R antibody (CAB0590). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
View AllClose

0 Reviews

View AllClose

Related Products

Human CD136/MST1R Recombinant Protein (RPES0780)

Human CD136/MST1R Recombinant Protein (RPES0780)

Immunology Recombinant Proteins

system_update_altDatasheetHuman CD136/MST1R Recombinant Protein The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron rec