Cell Biology Antibodies 12

Anti-MSRB2 Antibody (CAB8364)

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SKU:
CAB8364
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MSRB2 Antibody
Antibody SKU:CAB8364
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-182 of human MSRB2 (NP_036360.3).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse heart, Mouse kidney, Mouse brain, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 10-182 of human MSRB2 (NP_036360.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GLTL GTAP RRAV RGQA GGGG PGTG PGLG EAGS LATC ELPL AKSE WQKK LTPE QFYV TREK GTEP PFSG IYLN NKEA GMYH CVCC DSPL FSSE KKYC SGTG WPSF SEAH GTSG SDES HTGI LRRL DTSL GSAR TEVV CKQC EAHL GHVF PDGP GPNG QRFC INSV ALKF KPRK H
Gene ID:22921
Uniprot:Q9Y3D2
Cellular Location:Mitochondrion
Calculated MW:19kDa
Observed MW:20kDa
Synonyms:MSRB2, CBS-1, CBS1, CGI-131, MSRB, PILB
Background:
UniProt Protein Function:MSRB2: Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. Belongs to the MsrB Met sulfoxide reductase family.
UniProt Protein Details:

Protein type:EC 1.8.4.-; Oxidoreductase; Mitochondrial; Transcription factor

Chromosomal Location of Human Ortholog: 10p12

Cellular Component: mitochondrion

Molecular Function:zinc ion binding; peptide-methionine (R)-S-oxide reductase activity; actin binding; transcription factor activity

Biological Process: protein repair; regulation of transcription, DNA-dependent; actin filament polymerization; response to oxidative stress

UniProt Code:Q9Y3D2
NCBI GenInfo Identifier:182676405
NCBI Gene ID:22921
NCBI Accession:Q9Y3D2.2
UniProt Secondary Accession:Q9Y3D2,Q17R44, Q4G1C7, Q9Y5W6,
UniProt Related Accession:Q9Y3D2
Molecular Weight:19,536 Da
NCBI Full Name:Methionine-R-sulfoxide reductase B2, mitochondrial
NCBI Synonym Full Names:methionine sulfoxide reductase B2
NCBI Official Symbol:MSRB2  
NCBI Official Synonym Symbols:CBS1; MSRB; PILB; CBS-1; CGI-131  
NCBI Protein Information:methionine-R-sulfoxide reductase B2, mitochondrial; pilin-like transcription factor
UniProt Protein Name:Methionine-R-sulfoxide reductase B2, mitochondrial
Protein Family:Methionine-R-sulfoxide reductase
UniProt Gene Name:MSRB2  
UniProt Entry Name:MSRB2_HUMAN
Anti-MSRB2 Polyclonal Antibody (CAB8364)Western blot analysis of extracts of various cell lines, using MSRB2 antibody (CAB8364) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
Anti-MSRB2 Polyclonal Antibody (CAB8364)Immunohistochemistry of paraffin-embedded human lung cancer using MSRB2 Rabbit pAb (CAB8364) at dilution of 1:200 (40x lens).
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