Immunology Antibodies 1
Anti-MSN Antibody (CAB12473)
- SKU:
- CAB12473
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-MSN Antibody |
| Antibody SKU: | CAB12473 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 458-557 of human MSN (NP_002435.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Jurkat, HepG2, DU145, HT-1080, NIH/3T3, Mouse thymus, Mouse lung, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 458-557 of human MSN (NP_002435.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KTRA ELKT AMST PHVA EPAE NEQD EQDE NGAE ASAD LRAD AMAK DRSE EERT TEAE KNER VQKH LKAL TSEL ANAR DESK KTAN DMIH AENM RLGR DKYK |
| Gene ID: | 4478 |
| Uniprot: | P26038 |
| Cellular Location: | Apical cell membrane, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton, microvillus membrane |
| Calculated MW: | 67kDa |
| Observed MW: | 80kDa |
| Synonyms: | MSN, HEL70, IMD50, moesin |
| Background: | Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. |
| UniProt Protein Function: | Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. |
| NCBI Summary: | Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P26038 |
| NCBI GenInfo Identifier: | 127234 |
| NCBI Gene ID: | 4478 |
| NCBI Accession: | P26038.3 |
| UniProt Secondary Accession: | P26038,P35241, P15311, P26041, P26043, P26040, O35763 P31977, |
| UniProt Related Accession: | P26038 |
| Molecular Weight: | 67,820 Da |
| NCBI Full Name: | Moesin |
| NCBI Synonym Full Names: | moesin |
| NCBI Official Symbol: | MSN |
| NCBI Official Synonym Symbols: | HEL70 |
| NCBI Protein Information: | moesin |
| UniProt Protein Name: | Moesin |
| UniProt Synonym Protein Names: | Membrane-organizing extension spike protein |
| UniProt Gene Name: | MSN |
| UniProt Entry Name: | MOES_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MSN antibody (CAB12473) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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