Cell Biology Antibodies 1
Anti-MSMB Antibody (CAB10092)
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- SKU:
- CAB10092
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MSMB Antibody |
| Antibody SKU: | CAB10092 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-114 of human MSMB (NP_002434.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SW480, 293T |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-114 of human MSMB (NP_002434.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VPGD STRK CMDL KGNK HPIN SEWQ TDNC ETCT CYET EISC CTLV STPV GYDK DNCQ RIFK KEDC KYIV VEKK DPKK TCSV SEWI I |
| Gene ID: | 4477 |
| Uniprot: | P08118 |
| Cellular Location: | Secreted |
| Calculated MW: | 8kDa/12kDa |
| Observed MW: | 16kDa |
| Synonyms: | MSMB, HPC13, IGBF, MSP, MSPB, PN44, PRPS, PSP, PSP-94, PSP57, PSP94 |
| Background: | The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. |
| UniProt Protein Function: | MSMB: Defects in MSMB are the cause of susceptibility to prostate cancer hereditary type 13 (HPC13). It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Belongs to the beta-microseminoprotein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: extracellular space; nucleus Disease: Prostate Cancer, Hereditary, 13 |
| NCBI Summary: | The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08118 |
| NCBI GenInfo Identifier: | 131436 |
| NCBI Gene ID: | 4477 |
| NCBI Accession: | P08118.1 |
| UniProt Secondary Accession: | P08118,P11999, Q13125, Q6IAY9, Q9UC59, B1API6, |
| UniProt Related Accession: | P08118 |
| Molecular Weight: | 114 |
| NCBI Full Name: | Beta-microseminoprotein |
| NCBI Synonym Full Names: | microseminoprotein, beta- |
| NCBI Official Symbol: | MSMB |
| NCBI Official Synonym Symbols: | MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94 |
| NCBI Protein Information: | beta-microseminoprotein; seminal plasma beta-inhibin; immunoglobulin binding factor; prostate secreted seminal plasma protein; prostate secretory protein of 94 amino acids |
| UniProt Protein Name: | Beta-microseminoprotein |
| UniProt Synonym Protein Names: | Immunoglobulin-binding factor; IGBF; PN44; Prostate secreted seminal plasma protein; Prostate secretory protein of 94 amino acids; PSP-94; PSP94; Seminal plasma beta-inhibin |
| Protein Family: | Methanesulfonate monooxygenase hydroxylase |
| UniProt Gene Name: | MSMB |
| UniProt Entry Name: | MSMB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MSMB antibody (CAB10092) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Immunohistochemistry of paraffin-embedded mouse stomach using MSMB antibody (CAB10092) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using MSMB antibody (CAB10092) at dilution of 1:100 (40x lens). |
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