Cell Biology Antibodies 8
Anti-MSI1 Antibody (CAB2609)
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- SKU:
- CAB2609
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MSI1 Antibody |
| Antibody SKU: | CAB2609 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MSI1 (NP_002433.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, 293T, Mouse brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MSI1 (NP_002433.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | METD APQP GLAS PDSP HDPC KMFI GGLS WQTT QEGL REYF GQFG EVKE CLVM RDPL TKRS RGFG FVTF MDQA GVDK VLAQ SRHE LDSK TIDP KVAF PRRA |
| Gene ID: | 4440 |
| Uniprot: | O43347 |
| Cellular Location: | Cytoplasm, Nucleus |
| Calculated MW: | 39kDa |
| Observed MW: | 42KDa |
| Synonyms: | MSI1 |
| Background: | This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. |
| UniProt Protein Function: | Musashi-1: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'- GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'- [GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. Belongs to the Musashi family. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 12q24 Molecular Function:RNA binding Biological Process: nervous system development |
| NCBI Summary: | This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43347 |
| NCBI GenInfo Identifier: | 51316193 |
| NCBI Gene ID: | 4440 |
| NCBI Accession: | O43347.1 |
| UniProt Secondary Accession: | O43347,Q96PU0, Q96PU1, Q96PU2, Q96PU3, |
| UniProt Related Accession: | O43347 |
| Molecular Weight: | 39,125 Da |
| NCBI Full Name: | RNA-binding protein Musashi homolog 1 |
| NCBI Synonym Full Names: | musashi RNA binding protein 1 |
| NCBI Official Symbol: | MSI1 |
| NCBI Protein Information: | RNA-binding protein Musashi homolog 1 |
| UniProt Protein Name: | RNA-binding protein Musashi homolog 1 |
| Protein Family: | RNA-binding protein |
| UniProt Gene Name: | MSI1 |
| UniProt Entry Name: | MSI1H_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MSI1 Polyclonal Antibody (CAB2609) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat lung using MSI1 antibody (CAB2609) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using MSI1 antibody (CAB2609) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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