Epigenetics & Nuclear Signaling Antibodies 1

Anti-MSH5 Antibody (CAB10121)

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SKU:
CAB10121
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MSH5 Antibody
Antibody SKU:CAB10121
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MSH5 (NP_751897.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse testis, Rat testis
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MSH5 (NP_751897.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MASL GANP RRTP QGPR PGAA SSGF PSPA PVPG PREA EEEE VEEE EELA EIHL CVLW NSGY LGIA YYDT SDST IHFM PDAP DHES LKLL QRVL DEIN PQSV VTSA KQDE NMTR FLGK LASQ EHRE PKRP EIIF LPSV DFGL EISK QRLL SGNY SFIP DAMT ATEK ILFL SSII PFDC LLTV RALG GLLK FLGR RRIG VELE DYNV SVPI LGFK KFML THLV NIDQ DTYS VLQI FKSE SHPS VYKV ASGL KEGL SLFG ILNR
Gene ID:4439
Uniprot:O43196
Cellular Location:
Calculated MW:91kDa/92kDa/93kDa/94kDa
Observed MW:100kDa
Synonyms:MSH5, G7, MUTSH5, NG23, POF13
Background:This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.
UniProt Protein Function:MSH5: Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis. Belongs to the DNA mismatch repair MutS family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: synaptonemal complex

Molecular Function:damaged DNA binding; mismatched DNA binding; protein binding

Biological Process: chiasma formation; meiotic mismatch repair; mismatch repair

NCBI Summary:This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
UniProt Code:O43196
NCBI GenInfo Identifier:3914060
NCBI Gene ID:4439
NCBI Accession:O43196.1
UniProt Secondary Accession:O43196,O60586, Q5BLU9, Q5SSR1, Q8IW44, Q9BQC7, B0V033 B0V034,
UniProt Related Accession:O43196
Molecular Weight:91,862 Da
NCBI Full Name:MutS protein homolog 5
NCBI Synonym Full Names:mutS homolog 5
NCBI Official Symbol:MSH5  
NCBI Official Synonym Symbols:G7; NG23; MUTSH5  
NCBI Protein Information:mutS protein homolog 5
UniProt Protein Name:MutS protein homolog 5
Protein Family:MutS protein
UniProt Gene Name:MSH5  
UniProt Entry Name:MSH5_HUMAN
Anti-MSH5 Antibody (CAB10121)Western blot analysis of extracts of various cell lines, using MSH5 antibody (CAB10121) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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