Cell Biology Antibodies 12

Anti-MS4A2 Antibody (CAB8543)

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SKU:
CAB8543
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MS4A2 Antibody
Antibody SKU:CAB8543
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MS4A2 (NP_000130.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HL-60, Raji
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MS4A2 (NP_000130.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDTE SNRR ANLA LPQE PSSV PAFE VLEI SPQE VSSG RLLK SASS PPLH TWLT VLKK EQEF LGVT QILT AMIC LCFG TVVC SVLD ISHI EGDI FSSF KAGY
Gene ID:2206
Uniprot:Q01362
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:26kDa
Observed MW:27kDa
Synonyms:MS4A2, APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1
Background:The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
NCBI Summary:The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
UniProt Code:Q01362
NCBI GenInfo Identifier:4503677
NCBI Gene ID:2206
NCBI Accession:NP_000130.1
UniProt Related Accession:Q01362
Molecular Weight:
NCBI Full Name:high affinity immunoglobulin epsilon receptor subunit beta isoform 1
NCBI Synonym Full Names:membrane spanning 4-domains A2
NCBI Official Symbol:MS4A2  
NCBI Official Synonym Symbols:APY; IGEL; IGER; ATOPY; FCERI; IGHER; MS4A1; FCER1B  
NCBI Protein Information:high affinity immunoglobulin epsilon receptor subunit beta
UniProt Protein Name:High affinity immunoglobulin epsilon receptor subunit beta
UniProt Synonym Protein Names:Fc epsilon receptor I beta-chain; IgE Fc receptor subunit beta; Membrane-spanning 4-domains subfamily A member 2
Protein Family:High affinity immunoglobulin epsilon receptor
UniProt Gene Name:MS4A2  
UniProt Entry Name:FCERB_HUMAN
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