Epigenetics & Nuclear Signaling Antibodies 2
Anti-MRPL51 Antibody (CAB15838)
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- SKU:
- CAB15838
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-MRPL51 Antibody |
| Antibody SKU: | CAB15838 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human MRPL51 (NP_057581.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse kidney, Rat heart, Rat kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human MRPL51 (NP_057581.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MAGN LLSG AGRR LWDW VPLA CRSF SLGV PRLI GIRL TLPP PKVV DRWN EKRA MFGV YDNI GILG NFEK HPKE LIRG PIWL RGWK GNEL QRCI RKRK MVGS RMFA DDLH NLNK RIRY LYKH FNRH GKFR |
| Gene ID: | 51258 |
| Uniprot: | Q4U2R6 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 15kDa |
| Observed MW: | 14kDa |
| Synonyms: | MRPL51, CDA09, HSPC241, MRP64, bMRP64 |
| Background: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. |
| UniProt Protein Function: | MRPL51: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 12p13.3-p13.1 Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrial ribosome Molecular Function:protein binding; structural constituent of ribosome Biological Process: mitochondrial translation; organelle organization and biogenesis; translation |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q4U2R6 |
| NCBI GenInfo Identifier: | 74762954 |
| NCBI Gene ID: | 51258 |
| NCBI Accession: | Q4U2R6.1 |
| UniProt Secondary Accession: | Q4U2R6,Q96Q57, Q9BQ36, Q9P0N7, |
| UniProt Related Accession: | Q4U2R6 |
| Molecular Weight: | 15,095 Da |
| NCBI Full Name: | 39S ribosomal protein L51, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L51 |
| NCBI Official Symbol: | MRPL51 |
| NCBI Official Synonym Symbols: | CDA09; MRP64; bMRP64; HSPC241 |
| NCBI Protein Information: | 39S ribosomal protein L51, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L51, mitochondrial |
| UniProt Synonym Protein Names: | bMRP-64; bMRP64 |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL51 |
| UniProt Entry Name: | RM51_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MRPL51 antibody (CAB15838) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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