Cell Biology Antibodies 16

Anti-MRPL41 Antibody (CAB17760)

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SKU:
CAB17760
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MRPL41 Antibody
Antibody SKU:CAB17760
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human MRPL41 (NP_115866.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:293T, PC-3, MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-137 of human MRPL41 (NP_115866.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MGVL AAAA RCLV RGAD RMSK WTSK RGPR SFRG RKGR GAKG IGFL TSGW RFVQ IKEM VPEF VVPD LTGF KLKP YVSY LAPE SEET PLTA AQLF SEAV APAI EKDF KDGT FDPD NLEK YGFE PTQE GKLF QLYP RNFL R
Gene ID:64975
Uniprot:Q8IXM3
Cellular Location:
Calculated MW:
Observed MW:15kDa
Anti-MRPL41 Antibody (CAB17760)Western blot - MRPL41 Polyclonal Antibody (CAB17760)
Synonyms:BMRP, MRP-L27, MRPL27, PIG3, RPML27, MRPL41
Background:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]
UniProt Protein Function:MRPL41: Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins. Belongs to the ribosomal protein L41 family.
UniProt Protein Details:

Protein type:Mitochondrial; RNA-binding

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrion; ribonucleoprotein complex

Molecular Function:protein binding; structural constituent of ribosome

Biological Process: apoptosis; cell cycle; mitochondrial translation; organelle organization and biogenesis; translation

NCBI Summary:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]
UniProt Code:Q8IXM3
NCBI GenInfo Identifier:74750734
NCBI Gene ID:64975
NCBI Accession:Q8IXM3.1
UniProt Secondary Accession:Q8IXM3,Q96Q49,
UniProt Related Accession:Q8IXM3
Molecular Weight:15,383 Da
NCBI Full Name:39S ribosomal protein L41, mitochondrial
NCBI Synonym Full Names:mitochondrial ribosomal protein L41
NCBI Official Symbol:MRPL41  
NCBI Official Synonym Symbols:BMRP; PIG3; MRPL27; RPML27; MRP-L27  
NCBI Protein Information:39S ribosomal protein L41, mitochondrial
UniProt Protein Name:39S ribosomal protein L41, mitochondrial
UniProt Synonym Protein Names:39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homolog
Protein Family:39S ribosomal protein
UniProt Gene Name:MRPL41  
UniProt Entry Name:RM41_HUMAN
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