Cell Biology Antibodies 14

Anti-MRPL40 Antibody (CAB18191)

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SKU:
CAB18191
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-MRPL40 Antibody
Antibody SKU:CAB18191
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human MRPL40 .
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549, U2OS, BxPC-3
Immunogen:Recombinant protein of human MRPL40 .
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:64976
Uniprot:Q9NQ50
Cellular Location:
Calculated MW:24kDa
Observed MW:24kDa
Anti-MRPL40 Antibody (CAB18191)Western blot - MRPL40 Polyclonal Antibody (CAB18191)
Synonyms:URIM, L40mt, NLVCF, MRPL22, MRP-L22, MRP-L40, MRPL40
Background:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.
UniProt Protein Function:MRPL40:
UniProt Protein Details:

Protein type:Mitochondrial

Chromosomal Location of Human Ortholog: 22q11.2

Cellular Component: mitochondrial inner membrane; mitochondrial ribosome; mitochondrion; nucleolus; nucleus

Molecular Function:protein binding

Biological Process: anatomical structure morphogenesis; mitochondrial translation; organelle organization and biogenesis

NCBI Summary:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NQ50
NCBI GenInfo Identifier:21263795
NCBI Gene ID:64976
NCBI Accession:Q9NQ50.1
UniProt Secondary Accession:Q9NQ50,O95134, B3KVZ7,
UniProt Related Accession:Q9NQ50
Molecular Weight:24,490 Da
NCBI Full Name:39S ribosomal protein L40, mitochondrial
NCBI Synonym Full Names:mitochondrial ribosomal protein L40
NCBI Official Symbol:MRPL40  
NCBI Official Synonym Symbols:URIM; L40mt; NLVCF; MRPL22; MRP-L22; MRP-L40  
NCBI Protein Information:39S ribosomal protein L40, mitochondrial
UniProt Protein Name:39S ribosomal protein L40, mitochondrial
UniProt Synonym Protein Names:Nuclear localization signal-containing protein deleted in velocardiofacial syndrome; Up-regulated in metastasis
Protein Family:39S ribosomal protein
UniProt Gene Name:MRPL40  
UniProt Entry Name:RM40_HUMAN
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