Anti-MRP2/ABCC2 Antibody (CAB9528)

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SKU:
CAB9528
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ABC30
Synonyms:
CMOAT
Synonyms:
DJS
Synonyms:
MRP2
Synonyms:
cMRP

Description

Product Name:MRP2/ABCC2 Rabbit mAb
Product Code:CAB9528
Size:20uL, 50uL, 100uL
Synonyms:ABC30, CMOAT, DJS, MRP2, cMRP
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human MRP2/ABCC2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HepG2, A-549
Immunogen:A synthesized peptide derived from human MRP2/ABCC2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:1244
Uniprot:Q92887
Calculated MW:174kDa
Observed MW:250KDa
UniProt Protein Function:ABCC2: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter, ABC family; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: intercellular canaliculus; cell surface; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function:protein domain specific binding; protein binding; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: prostaglandin transport; metabolic process; response to heat; response to estrogen stimulus; transport; response to arsenic; multidrug transport; response to methotrexate; response to oxidative stress; cellular chloride ion homeostasis; transmembrane transport

Disease: Dubin-johnson Syndrome

NCBI Summary:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
UniProt Code:Q92887
NCBI GenInfo Identifier:4557481
NCBI Gene ID:1244
NCBI Accession:NP_000383.1
UniProt Related Accession:Q92887
Molecular Weight:
NCBI Full Name:canalicular multispecific organic anion transporter 1
NCBI Synonym Full Names:ATP binding cassette subfamily C member 2
NCBI Official Symbol:ABCC2  
NCBI Official Synonym Symbols:DJS; MRP2; cMRP; ABC30; CMOAT  
NCBI Protein Information:canalicular multispecific organic anion transporter 1
UniProt Protein Name:Canalicular multispecific organic anion transporter 1
UniProt Synonym Protein Names:ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2
Protein Family:37S ribosomal protein
UniProt Gene Name:ABCC2  
UniProt Entry Name:MRP2_HUMAN
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