Signal Transduction Antibodies 2
Anti-MRP1 / ABCC1 Antibody (CAB3027)
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- SKU:
- CAB3027
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
| Antibody Name: | Anti-MRP1 / ABCC1 Antibody |
| Antibody SKU: | CAB3027 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human MRP1 / ABCC1 |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-549, HeLa, HepG2, Mouse liver |
| Immunogen: | A synthetic peptide of human MRP1 / ABCC1 |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4363 |
| Uniprot: | P33527 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 151-172kDa |
| Observed MW: | 172kDa |
| Synonyms: | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 |
| Background: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. |
| UniProt Protein Function: | ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter Chromosomal Location of Human Ortholog: 16p13.1 Cellular Component: membrane; integral to plasma membrane; plasma membrane Molecular Function:ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATPase activity; ATP binding Biological Process: response to drug; vitamin metabolic process; transport; cobalamin metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; transmembrane transport; water-soluble vitamin metabolic process |
| NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P33527 |
| NCBI GenInfo Identifier: | 296439301 |
| NCBI Gene ID: | 4363 |
| NCBI Accession: | P33527.3 |
| UniProt Secondary Accession: | P33527,O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99 Q9UQA0, A3RJX2, C9JPJ4, |
| UniProt Related Accession: | P33527 |
| Molecular Weight: | 1531 |
| NCBI Full Name: | Multidrug resistance-associated protein 1 |
| NCBI Synonym Full Names: | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
| NCBI Official Symbol: | ABCC1 |
| NCBI Official Synonym Symbols: | MRP; ABCC; GS-X; MRP1; ABC29 |
| NCBI Protein Information: | multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1de |
| UniProt Protein Name: | Multidrug resistance-associated protein 1 |
| UniProt Synonym Protein Names: | ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter |
| Protein Family: | 37S ribosomal protein |
| UniProt Gene Name: | ABCC1 |
| UniProt Entry Name: | MRP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MRP1 / ABCC1 antibody (CAB3027) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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