Cell Biology Antibodies 12
Anti-MRC2 Antibody (CAB9858)
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- SKU:
- CAB9858
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MRC2 Antibody |
| Antibody SKU: | CAB9858 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-300 of human MRC2 (NP_006030.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SH-SY5Y, HeLa, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-300 of human MRC2 (NP_006030.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RWHC RTLG DQLS LLLG ARTS NISK PGTL ERGD QTRS GQWR IYGS EEDL CALP YHEV YTIQ GNSH GKPC TIPF KYDN QWFH GCTS TGRE DGHL WCAT TQDY GKDE RWGF CPIK SNDC ETFW DKDQ LTDS CYQF NFQS TLSW REAW ASCE QQGA DLLS ITEI HEQT YING LLTG YSST LWIG L |
| Gene ID: | 9902 |
| Uniprot: | Q9UBG0 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 166kDa |
| Observed MW: | 190kDa |
| Synonyms: | MRC2, CD280, CLEC13E, ENDO180, UPARAP |
| Background: | This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. |
| UniProt Protein Function: | MRC2: May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs). |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 17q23.2 Cellular Component: focal adhesion; membrane Molecular Function:collagen binding; protein binding Biological Process: collagen catabolic process; osteoblast differentiation |
| NCBI Summary: | This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9UBG0 |
| NCBI GenInfo Identifier: | 317373394 |
| NCBI Gene ID: | 9902 |
| NCBI Accession: | Q9UBG0.2 |
| UniProt Secondary Accession: | Q9UBG0,Q7LGE7, Q9Y5P9, A6H8K4, D3DU08, |
| UniProt Related Accession: | Q9UBG0 |
| Molecular Weight: | 166,674 Da |
| NCBI Full Name: | C-type mannose receptor 2 |
| NCBI Synonym Full Names: | mannose receptor C type 2 |
| NCBI Official Symbol: | MRC2 |
| NCBI Official Synonym Symbols: | CD280; UPARAP; CLEC13E; ENDO180 |
| NCBI Protein Information: | C-type mannose receptor 2 |
| UniProt Protein Name: | C-type mannose receptor 2 |
| UniProt Synonym Protein Names: | C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2; Urokinase-type plasminogen activator receptor-associated protein; UPAR-associated protein; Urokinase receptor-associated protein; CD_antigen: CD280 |
| Protein Family: | C-type mannose receptor |
| UniProt Gene Name: | MRC2 |
| UniProt Entry Name: | MRC2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MRC2 antibody (CAB9858) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 10s. |
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