Cell Biology Antibodies 12
Anti-MRAS Antibody (CAB8315)
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- SKU:
- CAB8315
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | MRAS Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8315 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 79-208 of human MRAS (NP_036351.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 79-208 of human MRAS (NP_036351.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EQYM RTGD GFLI VYSV TDKA SFEH VDRF HQLI LRVK DRES FPMI LVAN KVDL MHLR KITR EQGK EMAT KHNI PYIE TSAK DPPL NVDK AFHD LVRV IRQQ IPEK SQKK KKKT KWRG DRAT GTHK LQCV IL |
| Gene ID: | 22808 |
| Uniprot: | O14807 |
| Cellular Location: | Cell membrane, Cytoplasmic side, Lipid-anchor |
| Calculated MW: | 15kDa/23kDa |
| Observed MW: | 24kDa |
| Synonyms: | MRAS, M-RAs, R-RAS3, RRAS3 |
| Background: | This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
| UniProt Protein Function: | MRas: May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway. Belongs to the small GTPase superfamily. Ras family. |
| UniProt Protein Details: | Protein type:Oncoprotein; G protein, monomeric, Ras; G protein, monomeric; G protein Chromosomal Location of Human Ortholog: 3q22.3 Cellular Component: plasma membrane Molecular Function:GTPase activity; GTP binding; GTP-dependent protein binding Biological Process: muscle development; metabolic process; multicellular organismal development; Ras protein signal transduction; actin cytoskeleton organization and biogenesis |
| NCBI Summary: | This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | O14807 |
| NCBI GenInfo Identifier: | 145386506 |
| NCBI Gene ID: | 22808 |
| NCBI Accession: | NP_001078518.1 |
| UniProt Related Accession: | O14807 |
| Molecular Weight: | 24 kDa |
| NCBI Full Name: | ras-related protein M-Ras isoform 1 |
| NCBI Synonym Full Names: | muscle RAS oncogene homolog |
| NCBI Official Symbol: | MRAS |
| NCBI Official Synonym Symbols: | NS11; M-RAs; RRAS3; R-RAS3 |
| NCBI Protein Information: | ras-related protein M-Ras |
| UniProt Protein Name: | Ras-related protein M-Ras |
| UniProt Synonym Protein Names: | Ras-related protein R-Ras3 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | MRAS |
| UniProt Entry Name: | RASM_HUMAN |
 | Western blot analysis of extracts of mouse brain, using MRAS antibody (CAB8315) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 15s. |
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