Immunology Antibodies 2
Anti-MR1 Antibody (CAB8051)
- SKU:
- CAB8051
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| Antibody Name: | MR1 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB8051 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human MR1 (NP_001181928.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human MR1 (NP_001181928.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SDSR THSL RYFR LGVS DPIH GVPE FISV GYVD SHPI TTYD SVTR QKEP RAPW MAEN LAPD HWER YTQL LRGW QQMF KVEL KRLQ RHYN HSDN VAHT IKQA WEAN QHEL LYQK NWLE EECI AWLK RFLE YGKD TLQR TEPP LVRV NRKE TFPG VTAL FCKA HGFY PPEI YMTW MKNG EEIV QEID YGDI LPSG DGTY QAWA SIEL DPQS SNLY SCHV EHCG VHMV LQVP QESE TIPL VMKA V |
| Gene ID: | 3140 |
| Uniprot: | Q95460 |
| Cellular Location: | Cell membrane, Endoplasmic reticulum, Endoplasmic reticulum membrane, Extracellular side, Secreted, Single-pass membrane protein, Single-pass type I membrane protein |
| Calculated MW: | 25kDa/28kDa/34kDa/39kDa |
| Observed MW: | 42kDa |
| Synonyms: | MR1, HLALS |
| Background: | MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. |
| UniProt Protein Function: | MR1: Has antigen presentation function. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT cells are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand- dependent. Belongs to the MHC class I family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q25.3 Cellular Component: endoplasmic reticulum; plasma membrane Molecular Function:antigen binding; MHC class I receptor activity; protein binding Biological Process: antigen processing and presentation; immune response |
| NCBI Summary: | MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015] |
| UniProt Code: | Q95460 |
| NCBI GenInfo Identifier: | 74751679 |
| NCBI Gene ID: | 3140 |
| NCBI Accession: | Q95460.1 |
| UniProt Secondary Accession: | Q95460,O97985, O97986, Q53GM1, Q95HB8, Q9MY23, Q9NPL2 Q9TQB3, Q9TQB9, Q9TQK3, A8K2V9, B4E3B1, |
| UniProt Related Accession: | Q95460 |
| Molecular Weight: | 25,190 Da |
| NCBI Full Name: | Major histocompatibility complex class I-related gene protein |
| NCBI Synonym Full Names: | major histocompatibility complex, class I-related |
| NCBI Official Symbol: | MR1 |
| NCBI Official Synonym Symbols: | HLALS |
| NCBI Protein Information: | major histocompatibility complex class I-related gene protein |
| UniProt Protein Name: | Major histocompatibility complex class I-related gene protein |
| UniProt Synonym Protein Names: | Class I histocompatibility antigen-like protein |
| Protein Family: | Major histocompatibility complex class I-related gene protein |
| UniProt Gene Name: | MR1 |
| UniProt Entry Name: | HMR1_HUMAN |
 | Western blot analysis of extracts of mouse skeletal muscle, using MR1 antibody (CAB8051) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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