Signal Transduction Antibodies 1

Anti-MPZL1 Antibody (CAB13059)

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SKU:
CAB13059
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MPZL1 Antibody
Antibody SKU:CAB13059
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-269 of human MPZL1 (NP_003944.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:BxPC-3, HeLa, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-269 of human MPZL1 (NP_003944.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAS AGAG AVIA APDS RRWL WSVL AAAL GLLT AGVS ALEV YTPK EIFV ANGT QGKL TCKF KSTS TTGG LTSV SWSF QPEG ADTT VSFF HYSQ GQVY LGNY PPFK DRIS WAGD LDKK DASI NIEN MQFI HNGT YICD VKNP PDIV VQPG HIRL YVVE KENL PVFP VWVV VGIV TAVV LGLT LLIS MILA VLYR RKNS KRDY TGCS TSES LSPV KQAP RKSP SDTE GLVK SLPS GSHQ GPVI YAQL DHSG GHHS DKIN KSES VVYA DIRK N
Gene ID:9019
Uniprot:O95297
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:12kDa/15kDa/22kDa/28kDa/29kDa
Observed MW:16kDa
Synonyms:MPZL1, MPZL1b, PZR, PZR1b, PZRa, PZRb
Background:
UniProt Protein Function:PZR: an immunoglobulin superfamily cell surface protein. Contains two tyrosine-based inhibition motifs (ITIMs) responsible for binding of SHP-2. When phosphorylated, it can specifically bind SHP-2, blocking its translocation, and interupting its function. Treatment of several cell lines with ConA caused tyrosine phosphorylation of PZR. Two alternatively spliced isoforms have been reported. One isoform, PZR1b, lacks the ITIMs and has a dominant negative effect upon full-length PZR and its recruitment of SHP-2.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24.2

Cellular Component: focal adhesion; cell surface; integral to plasma membrane

Molecular Function:protein binding; structural molecule activity

Biological Process: cell-cell signaling; transmembrane receptor protein tyrosine kinase signaling pathway

UniProt Code:O95297
NCBI GenInfo Identifier:226054871
NCBI Gene ID:9019
NCBI Accession:NP_001139663.1
UniProt Related Accession:O95297
Molecular Weight:Observed: 29 kDaPredicted: 30 kDa
NCBI Full Name:myelin protein zero-like protein 1 isoform c
NCBI Synonym Full Names:myelin protein zero like 1
NCBI Official Symbol:MPZL1  
NCBI Official Synonym Symbols:PZR; PZRa; PZRb; PZR1b; MPZL1b  
NCBI Protein Information:myelin protein zero-like protein 1
UniProt Protein Name:Myelin protein zero-like protein 1
UniProt Synonym Protein Names:Protein zero-related
UniProt Gene Name:MPZL1  
UniProt Entry Name:MPZL1_HUMAN
Anti-MPZL1 Antibody (CAB13059)Western blot analysis of extracts of various cell lines, using MPZL1 antibody (CAB13059) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
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