Cell Biology Antibodies 7
Anti-MPZ Antibody (CAB1687)
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- SKU:
- CAB1687
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MPZ Antibody |
| Antibody SKU: | CAB1687 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human MPZ |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | A375, HT-1080, Mouse brain, Mouse heart, Rat brain |
| Immunogen: | Recombinant protein of human MPZ |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 4359 |
| Uniprot: | P25189 |
| Cellular Location: | Cell membrane, Myelin membrane, Single-pass type I membrane protein |
| Calculated MW: | 27kDa/34kDa |
| Observed MW: | 27kDa |
| Synonyms: | MPZ, CHM, CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0 |
| Background: | This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. |
| UniProt Protein Function: | myelin P0: a structural protein in peripheral nervous system Schwann cells. Forms an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. Defects cause of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, congenital hypomyelination neuropathy, and Roussy-Levy syndrome. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Adaptor/scaffold Chromosomal Location of Human Ortholog: 1q23.3 Biological Process: synaptic transmission Disease: Charcot-marie-tooth Disease, Axonal, Type 2i; Charcot-marie-tooth Disease, Axonal, Type 2j; Charcot-marie-tooth Disease, Demyelinating, Type 1b; Charcot-marie-tooth Disease, Dominant Intermediate D; Hypertrophic Neuropathy Of Dejerine-sottas; Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive; Roussy-levy Hereditary Areflexic Dystasia |
| NCBI Summary: | This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN). A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2015] |
| UniProt Code: | P25189 |
| NCBI GenInfo Identifier: | 127721 |
| NCBI Gene ID: | 4359 |
| NCBI Accession: | P25189.1 |
| UniProt Secondary Accession: | P25189,Q16072, Q5VTH4, Q92677, Q9BR67, |
| UniProt Related Accession: | P25189 |
| Molecular Weight: | 34,387 Da |
| NCBI Full Name: | Myelin protein P0 |
| NCBI Synonym Full Names: | myelin protein zero |
| NCBI Official Symbol: | MPZ |
| NCBI Official Synonym Symbols: | P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB |
| NCBI Protein Information: | myelin protein P0 |
| UniProt Protein Name: | Myelin protein P0 |
| UniProt Synonym Protein Names: | Myelin peripheral protein; MPP; Myelin protein zero |
| Protein Family: | Myelin protein |
| UniProt Gene Name: | MPZ |
| UniProt Entry Name: | MYP0_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MPZ antibody (CAB1687) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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