Cell Biology Antibodies 2
Anti-MPST Antibody (CAB11587)
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- SKU:
- CAB11587
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-MPST Antibody |
| Antibody SKU: | CAB11587 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-170 of human MPST (NP_066949.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse liver, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-170 of human MPST (NP_066949.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | LVSA QWVA EALR APRA GQPL QLLD ASWY LPKL GRDA RREF EERH IPGA AFFD IDQC SDRT SPYD HMLP GAEH FAEY AGRL GVGA ATHV VIYD ASDQ GLYS APRV WWMF RAFG HHAV SLLD GGLR HWLR QNLP LSSG KSQP A |
| Gene ID: | 4357 |
| Uniprot: | P25325 |
| Cellular Location: | Cell junction, Cytoplasm, Mitochondrion, synapse, synaptosome |
| Calculated MW: | 33kDa/35kDa |
| Observed MW: | 35kDa |
| Synonyms: | MPST, MST, TST2, TUM1 |
| Background: | This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. |
| UniProt Protein Function: | MPST: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. May have a role in cyanide degradation or in thiosulfate biosynthesis. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - cysteine and methionine; EC 2.8.1.2; Mitochondrial; Transferase Chromosomal Location of Human Ortholog: 22q12.3 Cellular Component: neuron projection Biological Process: cyanate catabolic process; response to toxin |
| NCBI Summary: | This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P25325 |
| NCBI GenInfo Identifier: | 6226903 |
| NCBI Gene ID: | 4357 |
| NCBI Accession: | P25325.3 |
| UniProt Secondary Accession: | P25325,O75750, Q6FHN9, A8MZ34, B3KP52, J3KPV7, |
| UniProt Related Accession: | P25325 |
| Molecular Weight: | 33kDa |
| NCBI Full Name: | 3-mercaptopyruvate sulfurtransferase |
| NCBI Synonym Full Names: | mercaptopyruvate sulfurtransferase |
| NCBI Official Symbol: | MPST |
| NCBI Official Synonym Symbols: | MST; TST2; TUM1 |
| NCBI Protein Information: | 3-mercaptopyruvate sulfurtransferase |
| UniProt Protein Name: | 3-mercaptopyruvate sulfurtransferase |
| Protein Family: | 3-mercaptopyruvate sulfurtransferase |
| UniProt Gene Name: | MPST |
 | Western blot analysis of extracts of various cell lines, using MPST antibody (CAB11587) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
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